6-HYDROXY-3-PYRIDINEBORONIC ACID Chemical Properties

Density 

1.36±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml,Ethanol: 1 mg/ml

form 

A crystalline solid

pka

8.02±0.20(Predicted)

color 

White to off-white

InChI

InChI=1S/C5H6BNO3/c8-5-2-1-4(3-7-5)6(9)10/h1-3,9-10H,(H,7,8)

InChIKey

YUOLAYZNDYRBEZ-UHFFFAOYSA-N

SMILES

B(C1C=CC(=O)NC=1)(O)O

Safety Information

RIDADR 

2811

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

2933399990

6-HYDROXY-3-PYRIDINEBORONIC ACID Usage And Synthesis

Uses

6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block, which can be used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors[1][2].

References

[1] Hendricks RT, et al. 3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase. Bioorg Med Chem Lett. 2009 Jan 15;19(2):410-4. DOI:10.1016/j.bmcl.2008.11.060
[2] Verheijen JC, et al. Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. DOI:10.1021/jm9013828

6-HYDROXY-3-PYRIDINEBORONIC ACID(903899-13-8)Related Product Information

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