2-Boc-amino-4-formylpyridine Chemical Properties

Melting point:

125-126℃

Boiling point:

308.8±27.0 °C(Predicted)

Density 

1.212

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

12.20±0.70(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933399990

2-Boc-amino-4-formylpyridine Usage And Synthesis

Synthesis

General procedure for the synthesis of tert-butyl (4-formylpyridin-2-yl)carbamate from (4-(hydroxymethyl)pyridin-2-yl)carbamate: Synthesis of compound 2G: tert-butyl (4-formylpyridin-2-yl)carbamate Compound 2F ((tert-butyl (4-(hydroxymethyl)pyridin-2-yl)carbamate, 2.5 g, 11.15 mmol, 1.00 eq.) was dissolved in dichloroethane (DCE, 25 mL) followed by addition of manganese dioxide (MnO2, 19.4 g, 223.14 mmol, 20.02 eq.). The reaction mixture was stirred at 70 °C overnight. Upon completion of the reaction, the solid catalyst was removed by filtration. The filtrate was concentrated to dryness under reduced pressure to afford 1.4 g (57% yield) of the target product compound 2G as a white solid.

References

[1] Synthesis, 2007, # 16, p. 2529 - 2533
[2] Patent: WO2003/103669, 2003, A1. Location in patent: Page 21
[3] Patent: WO2008/108958, 2008, A2. Location in patent: Page/Page column 32
[4] Patent: WO2008/108957, 2008, A2. Location in patent: Page/Page column 30
[5] Patent: WO2018/209132, 2018, A1. Location in patent: Paragraph 0526

2-Boc-amino-4-formylpyridine(304873-65-2)Related Product Information

• tert-butyl 2-bromothiazol-4-ylcarbamate
• 2-Boc-amino-4-formylpyridine
• ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)ISONICOTINATE
• 2-Boc-amino-4-pyridinecarboxylic acid
• (4-METHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER