Diethyl 2,6-pyridinedicarboxylate Chemical Properties

Melting point:

44°C

Boiling point:

188 °C / 12mmHg

Density 

1.165±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

-0.20±0.10(Predicted)

color 

White to Light yellow to Light orange

CAS DataBase Reference

15658-60-3(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

29333990

Diethyl 2,6-pyridinedicarboxylate Usage And Synthesis

Chemical Properties

Yellow to red crystalline powder

Synthesis

Pyridine-2,6-dicarboxylic acid (10.0g, 59.9mmol) was added into ethanol (120mL), then 3 drops of concentrated sulfuric acid were added. The mixture was heated to reflux for 8 hours. After evaporation of the solvent, the solid residue was washed with saturated Na2CO3 aqueous solution and extracted with chloroform for 3 times. The organic phase was dried with small amount of MgSO4. The solvent was removed to afford 1 as white powder (12.6g, 56.3mmol, yield = 94%). 1 H-NMR (400MHz, CDCl3) |? ppm 8.29 (d, J = 7.80 Hz, 2H), 8.01 (t, J = 7.80, 7.80 Hz, 1H), 4.50 (q, J = 7.12, 7.12, 7.12 Hz, 2H), 1.47 (t, J = 7.13, 7.13 Hz, 3H). 13C-NMR (100 MHz, CDCl3) |? ppm 164.6, 148.6, 138.2,127.8, 62.3,14.2,14.2. ESI MS: m/z = 224.1 [M+H]+ , 246.1 [M+Na]+ .

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