2-METHYL-1-(METHYLAMINO)PROPAN-2-OL Chemical Properties

Boiling point:

142-143 °C

Density 

0.8875 g/cm3(Temp: 23 °C)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

14.97±0.29(Predicted)

Appearance

Colorless to light yellow Liquid

Safety Information

RIDADR 

UN2735

HazardClass 

8

2-METHYL-1-(METHYLAMINO)PROPAN-2-OL Usage And Synthesis

Uses

2-?Methyl-?1-?(methylamino)?-?2-?propanol is a general reagent used in the synthesis of thiophene-anthranilamides which act as potent and orally active factor Xa inihibitors.

Synthesis

2-Methyl-1-(methylamino)propan-2-ol was prepared as follows: 1-chloro-2-methyl-2-propanol (103??L, 1.00 mmol) was dissolved in 40% methylamine methanol solution (0.5 mL) and stirred in a microwave chemical synthesis unit (CEMDiscover) for 15 min at 100??C at 100W. After cooling to room temperature, the solvent was removed by distillation under reduced pressure, acetonitrile (3 mL) was added and the precipitated solid was filtered off. After adding aqueous sodium bicarbonate (10 drops) to the filtrate, the solvent was removed by distillation under reduced pressure to give a crude concentrate of 2-methyl-1-(methylamino)propan-2-ol.