Danusertib
Danusertib Basic information
- Product Name:
- Danusertib
- Synonyms:
-
- PHA-739358
- (R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide,PHA739358
- Benzamide, 4-(4-methyl-1-piperazinyl)-N-(1,4,5,6-tetrahydro-5-((2R)- methoxyphenylacetyl)pyrrolo(3,4-C)pyrazol-3-yl)-
- Unii-m3X659D0fy
- Danusertib(PHA-739358)
- danusertib
- N-[5-((2R)-2-Methoxy-2-phenylethanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
- PHA-739358(Danusertib)
- CAS:
- 827318-97-8
- MF:
- C26H30N6O3
- MW:
- 474.55
- Product Categories:
-
- Inhibitor
- Apis
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 827318-97-8.mol
Danusertib Chemical Properties
- Melting point:
- >145°C (dec.)
- Boiling point:
- 664.1±55.0 °C(Predicted)
- Density
- 1.322
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.70±0.20(Predicted)
- color
- Pale Beige
- InChIKey
- XKFTZKGMDDZMJI-HSZRJFAPSA-N
- SMILES
- C(NC1=NNC2CN(C([C@H](OC)C3=CC=CC=C3)=O)CC=21)(=O)C1=CC=C(N2CCN(C)CC2)C=C1
Danusertib Usage And Synthesis
Uses
An Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia. It is a COVID19-related research product.
Uses
Danusertib is an Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia.
Definition
ChEBI: N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide is a member of piperazines.
Biological Activity
danusertib (previously known as pha-739358), a 3-aminopyrazole derivative identified during the development of the pyrrolopyrazole sub-series, is a potent small-molecule inhibitor of aurora kinases family members with a dominant inhibition for aurora b kinase (abk). this pan-aurora kinases inhibitor is also able to inhibit several tyrosine kinases, including t315i mutant, ret, trk-a and fibroblast growth factor receptor-1 (fgfr-1), which are involved in multiple malignancies, such as chronic myelogenous leukemia (cml), acute lymphoblastic leukemia (all), thyroid prostate and breast carcinoma. thus, in many previous studies, danusertib exhibits remarkable antitumor activity in a number of different xengorafts, spontaneous, and transgenic animal tumor models with a favorable pharmacokinetic and safety profile.carpinelli p, ceruti r, giorgini ml, cappella p, gianellini l, croci v, degrassi a, texido g, rocchetti m, vianello p, rusconi l, storici p, zugnoni p, arrigoni c, soncini c, alli c, patton v, marsiglio a, ballinari d, pesenti e, fancelli d, moll j. pha-739358, a potent inhibitor of aurora kinases with a selecyive target inhibiton profile relevant to cancer. mol cancer ther 2007; 6(12 pt 1): 3158-3168
in vivo
PHA-739358 (15 mg/kg twice a day, i.p.) and IM are well tolerated, and significantly inhibit proliferation of K562 cells andvirtually suppressed tumor growth during the 10-day treatment period[2]. In a subcutaneous murine xenograft model, danusertibsertib (2×15 mg/kg/d, i.p.) significantly reduces tumor growth in vivo compared with controls or mice treated with streptozotocine/5-fluorouracil[3].
target
Aurora A/B/C
IC 50
Aurora A: 13 nM (IC50); Aurora B: 79 nM (IC50); Aurora C: 61 nM (IC50)
DanusertibSupplier
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- sales@boylechem.com
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