Basic information Safety Supplier Related

TCPOBOP

Basic information Safety Supplier Related

TCPOBOP Basic information

Product Name:
TCPOBOP
Synonyms:
  • 3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE
  • 3,3',5,5'-TETRACHLORIDE-BPB
  • 1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE
  • TCPOBOP
  • 2,2’-(1,4-phenylenebis(oxy))bis(3,5-dichloro-pyridin
  • 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3μ,5,5μ-Tetrachloro-1,4-bis(pyridyloxy)benzene
  • 1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene
  • 1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene
CAS:
76150-91-9
MF:
C16H8Cl4N2O2
MW:
402.06
Mol File:
76150-91-9.mol
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TCPOBOP Chemical Properties

Boiling point:
444.8±45.0 °C(Predicted)
Density 
1.518±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >10 mg/mL
form 
solid
pka
-0.52±0.10(Predicted)
color 
white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
UT7145000

MSDS

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TCPOBOP Usage And Synthesis

Description

TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.

Uses

TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.

General Description

A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.

Biochem/physiol Actions

TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.

References

1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893

TCPOBOPSupplier

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