TCPOBOP
TCPOBOP Basic information
- Product Name:
- TCPOBOP
- Synonyms:
-
- 3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE
- 3,3',5,5'-TETRACHLORIDE-BPB
- 1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE
- TCPOBOP
- 2,2’-(1,4-phenylenebis(oxy))bis(3,5-dichloro-pyridin
- 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3μ,5,5μ-Tetrachloro-1,4-bis(pyridyloxy)benzene
- 1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene
- 1,4-Bis[(3,5-dichloropyridin-2-yl)oxy]benzene
- CAS:
- 76150-91-9
- MF:
- C16H8Cl4N2O2
- MW:
- 402.06
- Mol File:
- 76150-91-9.mol
TCPOBOP Chemical Properties
- Boiling point:
- 444.8±45.0 °C(Predicted)
- Density
- 1.518±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10 mg/mL
- form
- solid
- pka
- -0.52±0.10(Predicted)
- color
- white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- UT7145000
MSDS
- Language:English Provider:SigmaAldrich
TCPOBOP Usage And Synthesis
Description
TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.
Uses
TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.
General Description
A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.
Biochem/physiol Actions
TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.
References
1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893
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