methyl 3-(4-bromophenyl)propanoate Chemical Properties

Boiling point:

92℃/0.4Torr

Density 

1.389±0.06 g/cm3(Predicted)

refractive index 

1.5360 to 1.5400

storage temp. 

Sealed in dry,Room Temperature

form 

Solid

color 

Colorless to pale yellow

Safety Information

HS Code 

2916.39.7900

methyl 3-(4-bromophenyl)propanoate Usage And Synthesis

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 4709, 1989 DOI: 10.1016/S0040-4039(01)80781-4

Synthesis

To a 250 mL round bottom flask was added 3-(4-bromophenyl)propionic acid (5 g, 21.83 mmol, 1.00 equiv) and methanol (50 mL). Thionyl chloride (7.76 g, 65.23 mmol, 5.30 eq.) was added slowly and dropwise with stirring. The reaction mixture was stirred at 70 °C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of a water/ice mixture. The aqueous phase was extracted with ethyl acetate (200 mL × 3), the organic phases were combined, washed sequentially with brine (100 mL × 2), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with petroleum ether:ethyl acetate (5:2, v/v) as eluent to afford methyl 4-bromo-3-phenylpropionate (4.84 g, 91% yield) as a colorless oil.

References

[1] Patent: WO2018/39386, 2018, A1. Location in patent: Page/Page column 291; 292

methyl 3-(4-bromophenyl)propanoate(75567-84-9)Related Product Information

• 3-(2-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER
• 3-(4-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER
• ETHYL ISONICOTINOYLACETATE
• methyl 3-(2-bromophenyl)propanoate
• Methyl propionate