7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDRO- Chemical Properties

Melting point:

>30 °C(Solv: water (7732-18-5))

Boiling point:

559.8±23.0 °C(Predicted)

Density 

1.89±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

10.66±0.20(Predicted)

Appearance

Off-white to gray Solid

Safety Information

HS Code 

2933998090

7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDRO- Usage And Synthesis

Synthesis

GENERAL STEPS: Formamidine acetate (40.3 mmol, 4.2 g) was added to a mixed solution of Hunig base (40 mL) and n-butanol (n-BuOH, 40 mL) containing 1-tert-butyl 3-methyl 4-amino-1H-pyrazole-1,3-dicarboxylic acid (26, 8.85 g, 36.7 mmol). The reaction mixture was heated with stirring at 110 °C for 1 hour. After completion of the reaction, it was cooled to room temperature and the precipitated solid product was collected. The solid was washed with dichloromethane and then dried under reduced pressure to afford 7-hydroxypyrazolo[4,3-D]pyrimidine (27, 4.46 g, 89% yield). The structure of the product was confirmed by electrospray mass spectrometry (ES(+)MS), m/e = 137.

References

[1] Patent: US2007/27166, 2007, A1. Location in patent: Page/Page column 84-85

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