FGIN-1-27 Chemical Properties

Melting point:

96-97 °C

Boiling point:

608.3±55.0 °C(Predicted)

Density 

1.0538 (estimate)

storage temp. 

2-8°C

solubility 

methanol: 20 mg/mL

form 

White powder.

pka

16.45±0.30(Predicted)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29339980

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

FGIN-1-27 Usage And Synthesis

Chemical Properties

white to off-white powder

Uses

FGIN-1-27 is a potent inositol monophosphatase inhibitor.

Definition

ChEBI: 2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide is a phenylindole.

Biological Activity

Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC 50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.

storage

Room temperature

FGIN-1-27(142720-24-9)Related Product Information

• Flumazenil
• 5-(4-METHOXYPHENYL)PYRROLO[2,1-D][1,5]BENZOTHIAZEPIN-4-OL N,N-DIMETHYLCARBAMATE
• 1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE
• NBD FGIN-1-27 ANALOG
• 5-PHENYLPYRROLO[2,1-D][1,5]-BENZOTHIAZEPIN-4-OL HEXANOATE
• 5-(4-METHOXYPHENYL)PYRROLO[2,1-D][1,5]BENZOTHIAZEPIN-4-OL ACETATE
• 3-HYDROXYMETHYL-BETA-CARBOLINE
• NBD FGIN-1-27 ANALOG
• N,N-DIHEXYL-2-PHENYLINDOLE-3-ACETAMIDE
• 3-methyl-2-phenyl-1H-indole
• 2-(2-PHENYL-1H-INDOL-3-YL)-ETHYLAMINE
• (2-PHENYL-1H-INDOL-3-YL)-ACETALDEHYDE
• N,N-DI-N-HEXYLACETAMIDE
• 6-(4-FLUOROPHENYL)INDOLE
• INDOLE-3-(N,N-DIMETHYL)ACETAMIDE
• FGIN-1-27