PROSTACYCLIN SODIUM SALT Chemical Properties

Melting point:

168-170 °C

RTECS 

UK8008700

storage temp. 

-20°C

solubility 

H₂O: 1 mg/mL Hydrolyzes to 6-ketoprostaglandin F_1α in aqueous solution.

form 

powder

color 

white

Water Solubility 

Soluble to 100 mM in water

Sensitive 

Moisture Sensitive

Merck 

13,7967

BRN 

6472195

Stability:

Light Sensitive, Temperature Sensitive

CAS DataBase Reference

61849-14-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

22-26-36

WGK Germany 

3

F 

3-10

HS Code 

29329900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

PROSTACYCLIN SODIUM SALT Usage And Synthesis

Description

Epoprostenol is a naturally occurring prostaglandin indicated for the preservation of platelet function during cardiopulmonary bypass, prevention of platelet aggregation during charcoal hemoperfusion of patients in hepatic failure, and as an alternative to heparin during renal dialysis.

Chemical Properties

Epoprostenol is white crystalline powder

Originator

Burroughs Wellcome (United Kingdom)

Uses

Prostaglandin I2 sodium salt has been used:

• in the preparation of stock solution for platelet washing procedure
• as supplement in platelet-rich-plasma, for platelet preparation
• to prevent platelet activation

Uses

Epoprostenol is an Eicosanoid which prevents the formation of platelet plugs and is an effective vasodilator.

Manufacturing Process

Preparation of prostacyclin:
Pig aortas were stripped of adventitia, snap frozen in liquid nitrogen, crushed into a fine powder, resuspended in 0.05 M Tris buffer (pH 7.5) (1:4, w:v) andhomogenised at high speed in a Polytron (KIMENATIC, LUCERNE, SWITZERLAND) homogenizer. The homogenate was centrifuged for 15 min and the resulting supernatant centrifuged again for 5 min. The pellet was discarded, while the pellet obtained after centrifugation of the supernatant was resuspended in deionized water and lyophilized. An average yield of 150 mg of aortic microsomal powder (51% protein) per 100 g of aortic tissue was obtained.

brand name

Flolan (GlaxoSmithKline);CYCLO-PROSTIN.

Therapeutic Function

Platelet aggregation inhibitor, Antimetastatic

Biological Activity

Epoprostenol is a potent agonist at IP prostanoid receptors. Inhibits platelet aggregation and induces vasodilation.

Biochem/physiol Actions

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

storage

Desiccate at -80°C

PROSTACYCLIN SODIUM SALT(61849-14-7)Related Product Information

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