BETA-CASOMORPHIN (BOVINE)
BETA-CASOMORPHIN (BOVINE) Basic information
- Product Name:
- BETA-CASOMORPHIN (BOVINE)
- Synonyms:
-
- H-TYR-PRO-PHE-PRO-GLY-PRO-ILE-OH
- BETA-CASOMORPHIN-7
- BETA-CASOMORPHIN-7 (BOVINE)
- BETA-CASOMORPHIN-7 (BOVINE) 4H2O
- BETA-CASOMORPHIN (BOVINE)
- BETA-CASOMORPHIN (1-7), BOVINE
- BETA CASOMORPHIN
- L-TYR-PRO-PHE-PRO-GLY-PRO-ILE
- CAS:
- 72122-62-4
- MF:
- C41H55N7O9
- MW:
- 789.92
- Product Categories:
-
- peptide
- Mol File:
- 72122-62-4.mol
BETA-CASOMORPHIN (BOVINE) Chemical Properties
- storage temp.
- -15°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
- Sequence
- Tyr-Pro-Phe-Pro-Gly-Pro-Ile
BETA-CASOMORPHIN (BOVINE) Usage And Synthesis
Uses
β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay[1].
in vivo
β-Casomorphin, bovine (7.5×106 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats[3].
β-Casomorphin, bovine (7.5×106 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats[3].
β-Casomorphin, bovine (7.5×106 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats[3].
β-Casomorphin, bovine (7.5×106 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].
| Animal Model: | Male Sprague-Dawley (SD) rats (200 g±10 g)[3] |
| Dosage: | 7.5×106 mol/day/kg |
| Administration: | Oral gavage; for 30 days |
| Result: | Increased plasma insulin and decreased plasma glucagon of diabetic rats. |
References
[1] Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9. DOI:10.1016/0024-3205(81)90297-6
[2] Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13. DOI:10.1152/ajpgi.00455.2005
[3] Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472. DOI:10.1371/journal.pone.0063472
BETA-CASOMORPHIN (BOVINE)Supplier
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BETA-CASOMORPHIN (BOVINE)(72122-62-4)Related Product Information
- BETA-CASOMORPHIN BOVINE FRAGMENT 1-5 HYDROCHLORIDE
- H-TYR-PRO-PHE-VAL-GLU-PRO-ILE-OH
- BETA-CASOMORPHIN (1-6) (BOVINE)
- α-Casomorphin (1-2)
- BETA-CASOMORPHIN (1-3)
- BETA-CASOMORPHIN (1-5) AMIDE (BOVINE)
- BETA-CASOMORPHIN (1-4) (BOVINE)
- β-Casomorphin (1-4), amide (bovine)
- β-Casomorphin (1-2) amide
- BETA-CASOMORPHIN (1-3) AMIDE
- L-Tyr-L-Pro-L-Phe-L-Pro-Gly-L-Pro-OH
- β-Casomorphin (1-5), amide, bovine
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