N-[12-[(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL)AMINO]DODECANOYL]-SPHINGANINE Chemical Properties

Density 

1.095±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml

form 

A solid

pka

14.30±0.20(Predicted)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-38-40-48/20/22

Safety Statements 

36/37

RIDADR 

UN 1888 6.1/PG 3

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

N-[12-[(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL)AMINO]DODECANOYL]-SPHINGANINE Usage And Synthesis

Uses

C-12 NBD-dihydro-Ceramide is a fluorescent ceramidase substrate. C-12 NBD-dihydro-Ceramide compound is a fluorescent ceramide analog which contains a saturated bond in the C4-C5 position of the sphingosine backbone. It can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources. C-12 NBD-dihydro-ceramide may exhibit reduced activity in ceramidase assays compared to C-12 NBD ceramide. This is based on the observation that saturation of the C4-C5 sphingosine bond in C16-ceramide results in approximately a 10-fold reduction in efficiency as a substrate for rat brain ceramidase compared to the unsaturated substrate. Yet, experimental characterization of C-12 NBD-dihydro-ceramide as a ceramidase substrate needs to be performed.