METHYL-(3-HYDROXYPROPYL) SULFONE Chemical Properties

Boiling point:

349.4±25.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

14.57±0.10(Predicted)

form 

solid

color 

White to off-white

Safety Information

Hazard Codes 

T

Risk Statements 

25-36

Safety Statements 

26-45

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

2905599890

Toxicity

mouse,LD50,intravenous,> 5gm/kg (5000mg/kg),Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 242, 1971.

METHYL-(3-HYDROXYPROPYL) SULFONE Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-methylsulfonyl-1-propanol from 3-methylthiopropanol: 3-methylthiopropanol (200 g, 1900 mmol) was dissolved in dichloromethane (2000 ml). The reaction mixture was cooled to 0°C. An 85% aqueous solution of m-chloroperoxybenzoic acid (970 g, 5700 mmol) was added in batches while maintaining the temperature between 0 and 5 °C. After the addition was completed, the reaction mixture was slowly warmed to 25 °C and the reaction was stirred at this temperature for 15 hours. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad. The filtrate was purified by fast column chromatography (eluent: petroleum ether/ethyl acetate = 3:1, followed by ethyl acetate/methanol = 10:1) to afford the target product 3-methylsulfonyl-1-propanol (75 g, 29% yield).

References

[1] Patent: WO2012/80447, 2012, A1. Location in patent: Page/Page column 18
[2] Patent: WO2012/80450, 2012, A1. Location in patent: Page/Page column 27
[3] Patent: WO2012/80449, 2012, A1. Location in patent: Page/Page column 20
[4] Patent: US2013/267555, 2013, A1. Location in patent: Paragraph 0092-0094
[5] Patent: WO2013/186335, 2013, A1. Location in patent: Page/Page column 78; 79

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