Eledoisin Chemical Properties

Melting point:

230 °C (decomp)

Boiling point:

1618.1±65.0 °C(Predicted)

Density 

1.289±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

DMF: 15 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml

form 

A crystalline solid

pka

4.19±0.10(Predicted)

color 

White to off-white

optical activity

-4422 (95% Acetic Acid)

Sequence

{Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2

InChIKey

AYLPVIWBPZMVSH-UHFFFAOYSA-N

SMILES

C(C1NC(=O)CC1)(N1CCCC1C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(O)=O)C(=O)NC(C)C(=O)NC(C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C(=O)N)CCSC)CC1C=CC=CC=1)=O

Safety Information

WGK Germany 

3

RTECS 

JX8688000

HS Code 

3504009000

MSDS

• Language:English Provider:SigmaAldrich

Eledoisin Usage And Synthesis

Uses

Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.

Definition

ChEBI: Eledoisin is a peptide.

in vivo

IC 50

NK2; NK3

Description

Eledoisin’s molecular weight is 1188.4 having an amino acid sequence of Glp-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2 and a molecular formula of C54H85N13O15S.

Background

Eledoisin is an undecapeptide formed in the venom gland of several species of octopuses and is used as a vasodilator and a contraction agent of extravascular smooth muscle.

References

[1] Lippe C, et al. Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin. Peptides. 2004 Nov;25(11):1971-5. DOI:10.1016/j.peptides.2004.06.014
[2] Severini C, et al. The tachykinin peptide family. Pharmacol Rev. 2002 Jun;54(2):285-322. DOI:10.1124/pr.54.2.285

Eledoisin(69-25-0)Related Product Information

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