Basic information Safety Supplier Related

Calcitriol-d6

Basic information Safety Supplier Related

Calcitriol-d6 Basic information

Product Name:
Calcitriol-d6
Synonyms:
  • (1a,3,5Z,7E)- 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol-d6
  • 1a,25-Dihydroxycholecalciferol-d6
  • 1a,25-Dihydroxyvitamin D3-d6
  • Calcijex-d6
  • Calcitriol-d6
  • Ro 21-5535-d6
  • Rocaltrol-d6
  • Silkis-d6
CAS:
78782-99-7
MF:
C27H38D6O3
MW:
423
Product Categories:
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Isotope Labeled Compounds
  • Pharmaceuticals
  • Isotope Labelled Compounds
Mol File:
78782-99-7.mol
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Calcitriol-d6 Chemical Properties

Melting point:
77-79°C
Flash point:
14℃
storage temp. 
-20°C
solubility 
Soluble in Chloroform
form 
Powder
color 
White to off-white
Stability:
Light and temperature sensitive
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Safety Information

RIDADR 
UN1170 - class 3 - PG 2 - Ethanol, solution
HS Code 
9999999999
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Calcitriol-d6 Usage And Synthesis

Description

Calcitriol-d6 is intended for us as an internal standard for the quantification of calcitriol by GC- or LC-MS. Calcitriol is synthesized from 7-dehydro cholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy vitamin D3, the principal circulating form of vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic

Uses

1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d6?can be used as an analytical standard for the quantitative analysis of dihydroxyvitamin D3?concentration in human serum via LC-MS.

General Description

1α,25-Dihydroxyvitamin D3?[1,25(OH)2D3], also known as calcitriol, plays a role in calcium and phosphate metabolism in humans. It also regulates insulin secretion and induces cellular differentiation.
1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d6?is a deuterated vitamin D3 wherein C-26 and C-27 carbon methyl protons are replaced by deuterium.

Calcitriol-d6Supplier

J & K SCIENTIFIC LTD.
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Chemvon Biotechnology Co., Ltd
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Chemsky(shanghai)International Co.,Ltd.
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Haoyuan Chemexpress Co., Ltd.
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