CI 1020
CI 1020 Basic information
- Product Name:
- CI 1020
- Synonyms:
-
- 3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone
- CI 1020
- PD 156707
- 2(5H)-Furanone, 3-(1,3-benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-
- CAS:
- 162256-50-0
- MF:
- C28H26O9
- MW:
- 506.5
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 162256-50-0.mol
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CI 1020 Chemical Properties
- storage temp.
- Store at +4°C
- solubility
- Soluble to 50 mM in DMSO
- form
- Powder
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CI 1020 Usage And Synthesis
Uses
A novel endothelin-A receptor antagonist, in hypoxic pulmonary hypertension.
Biological Activity
Highly selective, orally active, non-peptide endothelin-A receptor (ET A ) antagonist (IC 50 values are 0.3 and 480 nM for ET A and ET B receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration.
in vivo
CI-1020 (30 mg/kg, p.o.) represents full inhibition of the ET-A and has no significant effect on basal blood pressure in normotensive rats[2].
CI-1020 (40 mg/kg, p.o.) attenuates established pulmonary hypertension in rats previously exposed to chronic hypoxia[4].
| Animal Model: | normal rats [2] |
| Dosage: | 30 mg/kg |
| Administration: | oral administration (p.o.) |
| Result: | Inhibited the ET-A and has no significant effect on basal blood pressure in normotensive rats. |
| Animal Model: | basal blood pressure in normotensive rats[4] |
| Dosage: | 40 mg/kg/day |
| Administration: | oral administration (p.o.) |
| Result: | Reduced the increase in RV/LV+S and the percentage DEL induced by chronic hypoxia. Lowered the increase in pulmonary resistance in isolated perfused lungs significantly. |
IC 50
ETA: 0.3 nM (IC50)
CI 1020Supplier
J & K SCIENTIFIC LTD.
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- 18210857532; 18210857532
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3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
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Chemsky (shanghai) International Co.,Ltd
- Tel
- 021-50135380
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BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
EMMX Biotechnology LLC
- Tel
- 888-539-0666
- info@emmx.com
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CI 1020(162256-50-0)Related Product Information
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