2-Amino-5-bromo-6-methylpyridine Chemical Properties

Melting point:

79-84 °C(lit.)

Boiling point:

234.3±35.0 °C(Predicted)

Density 

1.5672 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

4.80±0.37(Predicted)

form 

Fluffy Powder

color 

White to off-white

Sensitive 

Hygroscopic

BRN 

114140

InChI

InChI=1S/C6H7BrN2/c1-4-5(7)2-3-6(8)9-4/h2-3H,1H3,(H2,8,9)

InChIKey

SEOZHXRTVJPQPZ-UHFFFAOYSA-N

SMILES

C1(N)=NC(C)=C(Br)C=C1

CAS DataBase Reference

42753-71-9(CAS DataBase Reference)

EPA Substance Registry System

2-Pyridinamine, 5-bromo-6-methyl- (42753-71-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-26/37/39

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29333999

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Amino-5-bromo-6-methylpyridine Usage And Synthesis

Application

2-Amino-5-bromo-6-methylpyridine is an important chemical raw material or intermediate, widely used in the synthesis of pyridine drugs, and also has potential effects such as antibacterial, antidepressant, insecticidal, herbicidal, and antimicrobial properties.

Chemical Properties

Light yellow Cryst

Synthesis

General steps: Example 2 Add 650 g of xylene as solvent to the reactor and heat to 115-120°C. The heating was continued under reflux conditions until the water was completely removed. The solvent was cooled to 70°C under nitrogen protection. Subsequently, 22 g of sodium amide was added and the solution was heated to 118-120 °C. Under reflux condition, 102 g of 2-bromo-3-methylpyridine was slowly added dropwise, and after completion of the dropwise addition, the reaction temperature was maintained at reflux for 1 hour. Upon completion of the reaction, the reaction solution was cooled to 45 °C. The reaction solution was then poured into ice water and the upper organic phase was separated. The xylene was concentrated under atmospheric pressure to 220 g remaining and cooled to 10-15 °C with stirring. After crystallization, 100 g of the target product 2-amino-5-bromo-6-methylpyridine was obtained with 99.3% purity and 90.1% yield.

References

[1] Patent: CN105348181, 2016, A. Location in patent: Paragraph 0023; 0024; 0025

2-Amino-5-bromo-6-methylpyridine(42753-71-9)Related Product Information

• Dibenzylamine
• 1-Hexadecylpyridinium bromide
• Triallylamine
• 2-Amino-5-methylpyridine
• Bis(2-ethylhexyl)amine
• 2,6-Lutidine
• 2-Amino-5-bromopyridine
• ALTRENOGEST
• 2-Picoline
• 2-Amino-6-methylpyridine
• 3-Aminophenol
• 2-Aminopyridine
• 2-Bromo-6-methylpyridine
• 4-Dimethylaminopyridine
• Glycine
• 6-Aminocaproic acid
• Tris(hydroxymethyl)aminomethane
• 3-Aminopyridine