3,20-Dioxopregn-4-en-17-beta-yl acetate Chemical Properties

Melting point:

198 °C

Boiling point:

490.2±45.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

InChI

InChI=1/C23H32O4/c1-14(24)23(27-15(2)25)12-9-20-18-6-5-16-13-17(26)7-10-21(16,3)19(18)8-11-22(20,23)4/h13,18-20H,5-12H2,1-4H3/t18-,19+,20+,21+,22+,23-/s3

InChIKey

VTHUYJIXSMGYOQ-NCZDLRRGNA-N

SMILES

O([C@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)C)C(=O)C |&1:1,4,6,16,18,22,r|

CAS DataBase Reference

17308-02-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

40-48

Safety Statements 

22-24/25-45

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

TU5074000

MSDS

• Language:English Provider:SigmaAldrich

3,20-Dioxopregn-4-en-17-beta-yl acetate Usage And Synthesis

Uses

3,20-Dioxopregn-4-en-17-beta-yl acetate, also known as 17-Hydroxyprogesterone acetate, is a new steroid for oral administration. It has a progestational activity which is at least twice that of anhydrohydroxyprogesterone[1].

Mechanism of action

3,20-Dioxopregn-4-en-17-beta-yl acetate could induces secretory changes in the endometrium and luteal changes in the exfoliated vaginal epithelial cells, reduces fern-like patterns of the cervical mucus, causes a rise of basal body temperature, and induces withdrawal bleeding in castrates[1].

References

[1] Davis M, et al. 17-α-HYDROXYPROGESTERONE ACETATE; AN EFFECTIVE PROGESTATIONAL SUBSTANCE ON ORAL ADMINISTRATION. The Journal of clinical endocrinology and metabolism, 1957; 17: 1237–1244,.

3,20-Dioxopregn-4-en-17-beta-yl acetate(17308-02-0)Related Product Information

• Tocopheryl acetate
• Vinyl acetate
• Sodium acetate
• Glatiramer acetate
• 3'-Hydroxyacetophenone
• Potassium Acetate
• 2'-Hydroxyacetophenone
• 4'-Hydroxyacetophenone
• Pregnenolone acetate
• Ethyl acetate
• 16-Denyprasterone acetate
• Methyl acetate
• 19-Norethindrone acetate
• Butyl acetate
• ACETATE
• Hydroxyprogesterone caproate
• Hydrocortisone
• Amebucort