n-Dodecyl-beta-D-maltoside Chemical Properties

Melting point:

224-226 °C(lit.)

alpha 

47.5 º (c=1, water)

Boiling point:

703.5±60.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMF: 20 mg/ml
DMSO: 10 mg/ml
Ethanol: 10 mg/mlPBS (pH 7.2): 2 mg/ml

pka

12.82±0.70(Predicted)

form 

Powder

color 

White to off-white

Water Solubility 

soluble

BRN 

55318

Stability:

Stable, but store cool. Incompatible with strong oxidizing agents.

Major Application

(solubilizing, purifying, and stabilizing membrane proteins)

InChIKey

NLEBIOOXCVAHBD-KJPZNAOGNA-N

SMILES

O([C@]1([H])[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@H]1[C@@H]([C@@H](O)[C@H](OCCCCCCCCCCCC)O[C@@H]1CO)O |&1:1,3,4,6,8,13,14,15,17,32,r|

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36/37/39

WGK Germany 

3

F 

3-10

HS Code 

29400090

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

n-Dodecyl-beta-D-maltoside Usage And Synthesis

Chemical Properties

white powder

Uses

N-dodecyl-β-D-maltoside is used as a non-ionic detergent for stabilization and activation of enzymes and for membrane research. It has also been used for the isolation of the mitochondrial cytochrome c oxidize.

Definition

ChEBI: A glycoside resulting from attachment of a dodecyl group to the reducing-end anomeric centre of a beta-maltose molecule.

General Description

Absorbance (10%, H₂O, 260 nm): <1.0.

References

[1] PHILIPP ELLINGER. Detergent screening and purification of the human liver ABC transporters BSEP (ABCB11) and MDR3 (ABCB4) expressed in the yeast Pichia pastoris.[J]. PLoS ONE, 2013: e60620. DOI: 10.1371/journal.pone.0060620
[2] SARAH L ROUSE. Dodecyl maltoside protects membrane proteins in vacuo.[J]. Biophysical journal, 2013, 105 3: 648-656. DOI: 10.1016/j.bpj.2013.06.025
[3] KOCH K W. Purification and identification of photoreceptor guanylate cyclase.[J]. The Journal of Biological Chemistry, 1991, 1 1: 8634-8637. DOI: 10.1016/s0021-9258(18)93021-8
[4] BÉATRICE DE FORESTA  Philippe C  Fernando HENAO. Cancellation of the cooperativity of Ca2+ binding to sarcoplasmic reticulum Ca2+-ATPase by the non-ionic detergent dodecylmaltoside[J]. The FEBS journal, 1994, 223 2: 359-369. DOI: 10.1111/j.1432-1033.1994.tb19002.x
[5] G. ZARDENETA P M H. Micelle-assisted protein folding. Denatured rhodanese binding to cardiolipin-containing lauryl maltoside micelles results in slower refolding kinetics but greater enzyme reactivation.[J]. The Journal of Biological Chemistry, 1992, 28 1: 5811-5816. DOI: 10.1016/s0021-9258(18)42625-7
[6] ANNE WALTER. The vesicle-to-micelle transition of phosphatidylcholine vesicles induced by nonionic detergents: effects of sodium chloride, sucrose and urea[J]. Biochimica et biophysica acta. Biomembranes, 2000, 1508 1: Pages 20-33. DOI: 10.1016/s0304-4157(00)00005-8

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