7-Hydroxyquinoline Chemical Properties

Melting point:

239-244 °C

Boiling point:

264.27°C (rough estimate)

Density 

1.1555 (rough estimate)

refractive index 

1.4500 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Powder

pka

pK1:5.48(＋1);pK2:8.85(0) (20°C)

color 

Beige to pale brown

Water Solubility 

454.3mg/L(20 ºC)

InChI

InChI=1S/C9H7NO/c11-8-4-3-7-2-1-5-10-9(7)6-8/h1-6,11H

InChIKey

XCRPPAPDRUBKRJ-UHFFFAOYSA-N

SMILES

N1C2C(=CC=C(O)C=2)C=CC=1

CAS DataBase Reference

580-20-1(CAS DataBase Reference)

NIST Chemistry Reference

7-Quinolinol(580-20-1)

EPA Substance Registry System

7-Quinolinol (580-20-1)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-20/21/22-22

Safety Statements 

36/37/39-26

RTECS 

VC4160000

HazardClass 

IRRITANT

HS Code 

29334900

MSDS

• Language:English Provider:7-Hydroxyquinoline
• Language:English Provider:ACROS

7-Hydroxyquinoline Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Definition

ChEBI: A monohydroxyquinoline carrying a hydroxy substituent at position 7.

Synthesis

The general procedure for the synthesis of 7-hydroxyquinoline from acrolein diethyl acetal and 3-aminophenol was as follows: the reaction was carried out in a Panasonic NN-K5541JF microwave reactor equipped with a magnetic stirring device. The typical operation was as follows: acrolein diethyl acetal (1 mmol), excess 3-aminophenol (4 mmol) and solid catalyst were added to a round bottom flask; subsequently, the mixture was placed in a microwave reactor. The reaction was carried out by continuous microwave radiation under reflux and stirring conditions for 1 to 40 min. Upon completion of the reaction, the products were analyzed and identified using a Varian Saturn 2200/CP-3800 gas chromatography-mass spectrometer (GC-MS) equipped with two CP8944 capillary columns (VF-5, 30 m × 0.25 mm × 0.25 μm).

References

[1] Catalysis Communications, 2018, vol. 115, p. 21 - 25

7-Hydroxyquinoline(580-20-1)Related Product Information

• 4-Hydroxyquinoline
• Quinhydrone
• 2-Quinolinol
• 6-Hydroxyquinoline
• 3-Hydroxyquinoline
• 8-HYDROXYQUINOLINE BASE
• 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• ETHYL 8-CHLORO[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE
• 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
• 7-Methoxy-4-quinolinol
• 2-Hydroxy-4-(trifluoromethyl)quinoline
• 5-Amino-8-hydroxyquinoline
• KYNURENIC ACID
• Tris(8-hydroxyquinolinato)erbium
• 2-AMINO-4-HYDROXYQUINOLINE HYDRATE
• 3-Chloro-4-hydroxy-1H-quinolin-2-one
• Ethyl 6,7-difluoro-2-ethylmercapto-4-hydroxyquinoline-3-carboxylate
• 2,4-DIHYDROXYQUINOLINE MONOSODIUM SALT