CHLORPYRIFOS-OXON
CHLORPYRIFOS-OXON Basic information
- Product Name:
- CHLORPYRIFOS-OXON
- Synonyms:
-
- 3,5,6-Trichloro-2-pyridyl diethyl phosphate
- Chloropyrifos oxon
- Chloropyrifos oxygen analog
- chloropyrifosoxon
- chlorpyrifos oxygen analogue
- Chlorpyrifos Oxon 100mg [5598-15-2]
- 6-Trichloro-2-pyridyl Diethyl Phosphate
- Chlorpyrifos-ethyl Oxon
- CAS:
- 5598-15-2
- MF:
- C9H11Cl3NO4P
- MW:
- 334.52
- Product Categories:
-
- Heterocycles
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Phosphorylating and Phosphitylating Agents
- Mol File:
- 5598-15-2.mol
CHLORPYRIFOS-OXON Chemical Properties
- Boiling point:
- 357.8±42.0 °C(Predicted)
- Density
- 1.461±0.06 g/cm3(Predicted)
- storage temp.
- 0-6°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Low-Melting Solid
- pka
- -5.28±0.10(Predicted)
- color
- Off-White to Pale Beige
- Water Solubility
- 0.52g/L(24 ºC)
- Stability:
- Hygroscopic, Moisture sensitive
- EPA Substance Registry System
- Chlorpyrifos O.A. (5598-15-2)
CHLORPYRIFOS-OXON Usage And Synthesis
Chemical Properties
solid
Uses
Chlorpyrifos Oxon is a metabolite of Chlorpyrifos (C425300) in human.
in vivo
Chlorpyrifos-oxon (CPO) is rapidly detoxified by human liver microsomes via CYP-dependent deethylation and dearylation, and by glutathione-S-transferase. In addition, reactions with A-esterases such as paraoxonase 1 (PON 1) or B-esterases such as carboxylesterase and butyrylcholinesterase (BChE) in the liver may rapidly degrade or scavenge Chlorpyrifos-oxon[1].
Chlorpyrifos-oxon (3 mg/kg, ip; once; wild-type mice) treatment shows the dimensions of microtubules from Chlorpyrifos-oxon-treated mice are about 60% of those from control mice. The microtubules from mice exposed to Chlorpyrifos-oxon have covalently modified amino acids and abnormal structure, suggesting disruption of microtubule function[4].
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