2-Isopropylphenol Chemical Properties

Melting point:

12-16 °C (lit.)

Boiling point:

212-213 °C (lit.)

Density 

1.012 g/mL at 25 °C (lit.)

vapor pressure 

<0.05 mm Hg ( 25 °C)

FEMA 

3461 | 2-ISOPROPYLPHENOL

refractive index 

n20/D 1.526(lit.)

Flash point:

192 °F

storage temp. 

Store below +30°C.

solubility 

insoluble

form 

Liquid

pka

10.49±0.10(Predicted)

color 

Clear slightly yellow

Odor

at 0.10 % in propylene glycol. medicinal creosote phenolic

Odor Type

phenolic

Water Solubility 

insoluble

JECFA Number

697

BRN 

1363322

InChIKey

CRBJBYGJVIBWIY-UHFFFAOYSA-N

LogP

2.82

CAS DataBase Reference

88-69-7(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 2-(1-methylethyl)-(88-69-7)

EPA Substance Registry System

o-Isopropylphenol (88-69-7)

Safety Information

Hazard Codes 

C,Xn

Risk Statements 

34-22

Safety Statements 

26-36/37/39-45-28

RIDADR 

UN 3145 8/PG 2

WGK Germany 

3

RTECS 

SL5900000

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29071900

MSDS

• Language:English Provider:2-Isopropylphenol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Isopropylphenol Usage And Synthesis

Description

2-Isopropylphenol is medicinal, creosote.

Chemical Properties

2-Isopropylphenol has a medicinal, creosote odor

Chemical Properties

CLEAR SLIGHTLY YELLOW LIQUID

Occurrence

Reported found in Japanese whiskey, Romano cheese and dried bonito

Uses

2-Isopropylphenol was used to study the ability of 2-isopropylphenol to activate estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR) and estrogen-related receptor (ERR).

Uses

2-Isopropylphenol is an impurity of Propofol (P829750).

Definition

ChEBI: A member of the class of phenols carrying an isopropyl group at position 2.

Aroma threshold values

Detection: 1 ppb

General Description

Light-yellow liquid. Less dense than water and insoluble in water. Hence floats on water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Phenols, such as 2-Isopropylphenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon dioxide and carbon monoxide, may be formed when involved in fire [USCG, 1999].

Health Hazard

Exposure can cause irritation of eyes, nose and throat.

Fire Hazard

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon dioxide and carbon monoxide, may be formed when involved in fire.

2-Isopropylphenol(88-69-7)Related Product Information

• M-ISOPROPYLPHENOL,3-ISOPROPYLPHENOL,Isopropylphenol, meta,3-ISOPROPYLPHENOL 97+%,3-ISOPROPYLPHENOL 98%,META-ISOPROPYLPHENOL,3-ISOPROPYLPHENOL 98+%
• Phenol
• 2-ISOPROPYLANILINE
• Ipratropium bromide
• Diisopropylamine
• ISOPROPYLHYDRAZINE HYDROCHLORIDE
• Cuminaldehyde
• Triisopropylsilane
• Lithium diisopropylamide
• Cumene
• N,N-Diisopropylethylamine
• Chloromethyl isopropyl carbonate
• Carvacrol
• Propofol
• p-Isopropylphenol,PARA-ISOPROPYLPHENOL,4-ISOPROPYLPHENOL,4-ISOPROPYLPHENOL 98+%,4-Isopropylphenol 98%
• 2,4-DIISOPROPYLPHENOL
• 2,6-Diisopropyl-1,4-benzoquinone
• 3,6-Diisopropyl-1,2-benzenediol