Difluoxacin hydrochloride
Difluoxacin hydrochloride Basic information
- Product Name:
- Difluoxacin hydrochloride
- Synonyms:
-
- VETRANAL
- 6-FLUORO-1-(4-FLUOROPHENYL)-1,4-DIHYDRO-7-(4-METHYLPIPERAZINO)-4-OXO-3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE
- DIFLUOXACIN HYDROCHLORIDE
- DIFLOXACIN HCL
- DIFLOXACIN HYDROCHLORIDE
- Difluoxacin HCL
- 6-Fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid hydrochloride
- 3-Quinolinecarboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monohydrochloride
- CAS:
- 91296-86-5
- MF:
- C21H20ClF2N3O3
- MW:
- 435.85
- EINECS:
- 1806241-263-5
- Product Categories:
-
- DICURAL
- Active Pharmaceutical Ingredients
- Chiral Reagents
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API
- Mol File:
- 91296-86-5.mol
Difluoxacin hydrochloride Chemical Properties
- Melting point:
- >245°C (dec.)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in aqueous buffer
- form
- powder
- color
- White to off-white
- InChI
- InChI=1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H
- InChIKey
- JFMGBGLSDVIOHL-UHFFFAOYSA-N
- SMILES
- C12C=C(C(F)=CC=1C(C(C(=O)O)=CN2C1=CC=C(F)C=C1)=O)N1CCN(C)CC1.Cl
- CAS DataBase Reference
- 91296-86-5(CAS DataBase Reference)
Difluoxacin hydrochloride Usage And Synthesis
Brand Name(s) in US
Dicural
Description
Difloxacin is a fluoroquinolone antibiotic. It is active against isolates of anaerobic bacteria, including B. fragilis, as well as Fusobacterium and Actinomyces species with MIC values ranging from ≤0.125 to 8 μg/ml. It eliminates E. coli and B. fragilis infection in a rat intra-abdominal abscess model when administered at a dose of 40 mg/kg three times per day.
Chemical Properties
Off-White to Pale Yellow Solid
Uses
antibacterial, DNA gyrase inhibitor
Uses
A quinolone antibacterial compound. Structurally related to norfloxacin
Uses
A fluoroquinolone antibacterial structurally related to norfloxacin.
References
[1] M B BANSAL H T. Activity of difloxacin (A-56619) and A-56620 against clinical anaerobic bacteria in vitro.[J]. Antimicrobial Agents and Chemotherapy, 1987, 31 4: 619-621. DOI: 10.1128/aac.31.4.619
[2] H THADEPALLI S K C S V Gollapudi. Therapeutic evaluation of difloxacin (A-56619) and A-56620 for experimentally induced Bacteroides fragilis-associated intra-abdominal abscess.[J]. Antimicrobial Agents and Chemotherapy, 1986, 30 4: 574-576. DOI: 10.1128/aac.30.4.574
Difluoxacin hydrochlorideSupplier
- Tel
- 0592-6055939 18950006030
- lzf@xmweijia.com
- Tel
- 13564510648
- 2985380065@qq.com
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 86-21-63210123
- sj_scrc@sinopharm.com
Difluoxacin hydrochloride(91296-86-5)Related Product Information
- NORFLOXACIN HYDROCHLORIDE
- Quinclorac
- Ethoxyquin
- Ofloxacin hydrochloride
- Difloxacin
- 2-Ethylhexyl ferulate
- Levodropropizine
- N-Aminoethylpiperazine
- Topotecan hydrochloride
- Rufloxacin hydrochloride
- Isoquinoline
- 1-AdaMantanethylaMine
- Ciprofloxacin hydrochloride
- Sarafloxacin
- 3-Quinolinecarboxylic acid
- Sarafloxacin hydrochloride
- 4-FLUORODIPHENYLAMINE
- Difluoxacin hydrochloride