PROTOPORPHYRINATO ZINC Chemical Properties

RTECS 

ZG9210300

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO : 50 mg/mL (79.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)

form 

Crystalline

color 

Dark red to purple

Water Solubility 

Insoluble in water. Soluble in ethanol, and DMSO, pyridine, or dimethyl formamide.

Stability:

Hygroscopic

EPA Substance Registry System

Zincate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-4-2)- (15442-64-5)

Safety Information

WGK Germany 

3

TSCA 

Yes

PROTOPORPHYRINATO ZINC Usage And Synthesis

Uses

Zinc Protoporphyrin is a metabolite formed during biosynthesis and is used to evaluate iron nutrition and metabolism.

General Description

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC₅₀ = 800 nM, 4 μM, and 5 μM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.

Biological Activity

Inhibitor of heme oxygenase, which generates the putative neurotransmitter CO.

Biochem/physiol Actions

Primary Targetheme oxygenase

PROTOPORPHYRINATO ZINC(15442-64-5)Related Product Information

• Protoporphyrin IX
• 2,3,4,5-TETRAMETHYLPYRROLE
• Allylacetic acid
• ZINC NITRATE, TETRAHYDRATE
• 2,4-Dimethylpyrrole
• 2,5-Dimethyl-1H-pyrrole
• PROTOPORPHYRINATO ZINC
• 4-HEXENOIC ACID
• 3-BUTEN-1-AMINE
• 6-Heptenoic acid
• 3-METHYL-2-BUTEN-1-AMINE
• 1,3,6-HEPTATRIENE
• N-PROPYLETHYLIDENEAMINE
• 3,4-DIMETHYLPYRROLE
• 5-METHYL-4-HEXENOIC ACID
• 2,4-OCTADIENE
• HEPTA-4,6-DIENOIC ACID
• 3-ETHYL-2-METHYL-2-PENTENE