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PROTOPORPHYRINATO ZINC

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PROTOPORPHYRINATO ZINC Basic information

Product Name:
PROTOPORPHYRINATO ZINC
Synonyms:
  • PROTOPORPHYRINATO ZINC
  • dihydrogen [3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-N21,N22,N23,N24]zincate(4-)
  • Zinc protoporphyrin trihydrate
  • Zinc protoporphyrin trihydrate, 95+%
  • Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem
  • ZnPP
  • PROTOPORPHYRINATO ZINC ISO 9001：2015 REACH
  • Zinc Protoporphyrin IX DISCONTINUED, offer Z439970
CAS:
15442-64-5
MF:
C34H31N4O4Zn-
MW:
625.03
EINECS:
239-455-7
Product Categories:
  • Natural Porphyrins and Derivitives
  • Porphyrins
  • metal porphine (porphyrin) complex
  • 1
Mol File:
15442-64-5.mol
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PROTOPORPHYRINATO ZINC Chemical Properties

RTECS 
ZG9210300
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO : 50 mg/mL (79.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Crystalline
color 
Dark red to purple
Water Solubility 
Insoluble in water. Soluble in ethanol, and DMSO, pyridine, or dimethyl formamide.
λmax
426 nm
ε(extinction coefficient)
≥10000 at 585-591nm in pyridine
≥12000 at 548-554nm in pyridine
≥135000 at 423-429nm in pyridine
Stability:
Hygroscopic
InChIKey
FUTVBRXUIKZACV-RGGAHWMASA-K
SMILES
C(C1C(=C2C=C3C(C=C)=C(C)C4C=C5C(C=C)=C(C)C6=CC7C(C)=C(CCC(=O)[O-])C8N=7[Zn+2]([N-]56)(N3=4)[N-]2C=1C=8)C)CC(=O)[O-].[H+]
EPA Substance Registry System
Zincate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-4-2)- (15442-64-5)
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Safety Information

WGK Germany 
3
TSCA 
Yes
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PROTOPORPHYRINATO ZINC Usage And Synthesis

Uses

Zinc Protoporphyrin is a metabolite formed during biosynthesis and is used to evaluate iron nutrition and metabolism.

General Description

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 800 nM, 4 μM, and 5 μM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.

Biological Activity

Inhibitor of heme oxygenase, which generates the putative neurotransmitter CO.

Biochem/physiol Actions

Primary Targetheme oxygenase

in vivo

Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth[3].

Animal Model:BALB/c mice inoculated with C-26 cells[3]
Dosage:12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.
Administration:IP or PO; from day 7 to 19
Result:Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.

IC 50

Human Endogenous Metabolite

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