Piperiacetildenafil Chemical Properties

Melting point:

149-152oC

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform (Sparingly), Methanol (Slightly)

pka

10.09±0.20(Predicted)

form 

Solid

color 

White to Off-White

Piperiacetildenafil Usage And Synthesis

Uses

Piperiacetildenafil is an intermediate in the preparation of pyrazolopyrimidinones used in male sexual enhancement formulas

Synthesis

Piperacetildenafil was prepared as follows: piperidine (0.22 ml, 0.0022 mol) was added to a stirred 5-(5-bromoacetyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3 -d]pyrimidin-7- one (Preparation 8, 0.95 g, 0.0022 mol) and anhydrous potassium carbonate (0.6 g , 0.0044 mol) in acetonitrile (50 ml). After 18 h, the mixture was evaporated under vacuum, the residue was dissolved in water (50 ml) and the solution was extracted with ethyl acetate (3 x 30 ml). The organic extracts were combined, washed with brine (3 x 20 ml), dried (Na2SO4 ) and vacuum evaporated. The resulting yellow solid was chromatographically separated on silica gel (12 g) using an elution gradient of methanol in dichloromethane (0-2% methanol) to give an off-white solid. Crystallization with ethyl acetate-hexane gave the title compound piperacetildenafil as an off-white powder (0.27 g, 28%), m.p.

Piperiacetildenafil(147676-50-4)Related Product Information

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