azetidin-3-ylmethanol hydrochloride Chemical Properties

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

form 

powder to crystal

color 

White to Almost white

Sensitive 

Hygroscopic

InChI

InChI=1S/C4H9NO.ClH/c6-3-4-1-5-2-4;/h4-6H,1-3H2;1H

InChIKey

AQUVQGSNKVDBBF-UHFFFAOYSA-N

SMILES

C1NCC1CO.Cl

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37-60

TSCA 

No

HazardClass 

IRRITANT

HS Code 

2905599890

azetidin-3-ylmethanol hydrochloride Usage And Synthesis

Uses

3-Azetidinemethanol Hydrochloride is used in the synthesis of human rhinovirus inhibitors.

Synthesis

General procedure for the synthesis of 3-methylhydroxyazetidine hydrochloride from 1-Boc-3-hydroxymethylazetidine: compound 1-Boc-3-hydroxymethylazetidine (0.100 g, 0.534 mmol) was dissolved in dichloromethane (2 mL), followed by the addition of a solution of hydrogen chloride in dioxane (1 mL, 4 M). The reaction mixture was stirred at room temperature for 20 hours. After completion of the reaction, the mixture was concentrated to afford the target product 3-methylhydroxyazetidine hydrochloride (white solid, 0.060 g, yield: 90.91%).

References

[1] Patent: CN105732602, 2016, A. Location in patent: Paragraph 0410; 0411; 0412; 0413; 0414; 0415
[2] Patent: US2018/16252, 2018, A1. Location in patent: Paragraph 1112

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