2,2-Difluoroethanol Chemical Properties

Melting point:

-28°C

Boiling point:

95 °C

Density 

1.296

refractive index 

1.338

Flash point:

3°C

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

soluble in chloroform, ethanol.

form 

clear liquid

pka

13.00±0.10(Predicted)

color 

Colorless to Almost colorless

Specific Gravity

1.296

BRN 

1731617

CAS DataBase Reference

359-13-7(CAS DataBase Reference)

NIST Chemistry Reference

Difluoroethanol(359-13-7)

EPA Substance Registry System

2,2-Difluoroethanol (359-13-7)

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-20/21/22-36/37/38

Safety Statements 

16-36/37/39-45-60-37-33-26-7

RIDADR 

1987

Hazard Note 

Flammable

HazardClass 

3

PackingGroup 

II

HS Code 

29055900

MSDS

• Language:English Provider:2,2-Difluoroethanol
• Language:English Provider:ALFA

2,2-Difluoroethanol Usage And Synthesis

Chemical Properties

Colorless Liquid

Uses

2,2-Difluoroethanol is used as a chemical intermediates. It has wide applications in medicine and fluoropolymers.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 23, p. 985, 1980 DOI: 10.1021/jm00183a005

Synthesis

Example 13: Synthesis of 2,2-difluoroethanol from ethyl 2,2-difluoroacetate (Step b2) In a 0.5 L glass reactor equipped with a mechanical stirrer, reflux condenser and temperature probe, 164 g of ethyl 2,2-difluoroacetate (GC purity 95%), 106 g of methanol, and 3 g of solid NaOH were added. the reaction was carried out at 65 °C for 2 h until the conversion was complete. The 2,2-difluoroethanol was isolated by distillation to give 96.3% GC purity and 87% isolated yield.

References

[1] Patent: CN107986944, 2018, A. Location in patent: Paragraph 0020; 0023; 0026; 0029; 0032
[2] Patent: WO2009/40367, 2009, A1. Location in patent: Page/Page column 12
[3] Patent: US2014/243561, 2014, A1. Location in patent: Paragraph 0040; 0041; 0042
[4] Patent: WO2009/40367, 2009, A1. Location in patent: Page/Page column 10
[5] Patent: CN108178723, 2018, A. Location in patent: Paragraph 0015; 0016; 0018; 0020

2,2-Difluoroethanol(359-13-7)Related Product Information

• CHLORODIFLUOROACETIC ANHYDRIDE
• Trifluoroacetic anhydride
• Ethyl trifluoroacetate
• Methyl pentafluoropropionate
• TRIMETHYLSILYL TRIFLUOROACETATE
• TRIFLUOROACETALDEHYDE ETHYL HEMIACETAL
• METHYL CHLORODIFLUOROACETATE
• Heptafluorobutyric anhydride
• THALLIUM(III) TRIFLUOROACETATE
• (R)-(-)-2,2,2-TRIFLUORO-1-(9-ANTHRYL)ETHANOL
• 2,2,2-TRIFLUOROETHYL TRIFLUOROACETATE
• METHYL HEPTAFLUOROBUTYRATE
• 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE
• 2-METHOXY-2-PHENYL-3,3,3-TRIFLUOROPROPIONITRILE
• ETHYL HEPTAFLUOROBUTYRATE
• Methyl trifluoroacetate
• Perfluoropropionic anhydride
• 2,2,2-Trifluoroethyl acrylate