gamma-amanitin
gamma-amanitin Basic information
- Product Name:
- gamma-amanitin
- Synonyms:
-
- GAMMA-AMANITIN
- Cyclo[L-Asn-L-t4Hyp-[(4S)-4-hydroxy-L-Ile-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-]
- α-Amanitin, 3-[(4S)-4-hydroxy-L-isoleucine]-
- γ-Amanitin
- Dimethylacetamide Impurity 4 (Dimethylacetamide EP Impurity D)
- gamma-Amanitin, RNA polymerase II inhibitor
- CAS:
- 21150-23-2
- MF:
- C39H54N10O13S
- MW:
- 902.98
- Mol File:
- 21150-23-2.mol
gamma-amanitin Chemical Properties
- Boiling point:
- 1566.5±65.0 °C(Predicted)
- Density
- 1.1527 (rough estimate)
- refractive index
- 1.7400 (estimate)
- form
- White to off-white powder.
- pka
- 9.63±0.70(Predicted)
- color
- Colorless to light yellow
gamma-amanitin Usage And Synthesis
Uses
γ-Amanitin an ADC cytotoxin and isolated from the?mushroom. γ-Amanitin inhibits?RNA polymerase II and disrupts synthesis of?mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells[1][2][3].
in vivo
γ-amanitin (i.p.) is classified as a neutral amanitin with an LD50 in mice ranging from 0.2 to 0.5 mg/kg[3].
IC 50
Traditional Cytotoxic Agents
References
[1] He K, et al. Production of a broad-specificity monoclonal antibody and application as a receptor to detection amatoxins in mushroom. Biologicals. 2017 Sep;49:57-61. DOI:10.1016/j.biologicals.2017.06.008
[2] Gong M, et al. Amanitin-induced variable cytotoxicity in various cell lines is mediated by the different expression levels of OATP1B3. Food Chem Toxicol. 2024 Jun;188:114665. DOI:10.1016/j.fct.2024.114665
[3] Garcia J, et al. Amanita phalloides poisoning: Mechanisms of toxicity and treatment. Food Chem Toxicol. 2015 Dec;86:41-55. DOI:10.1016/j.fct.2015.09.008
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