2,2,6,6-Tetramethyl-4-piperidinol Chemical Properties

Melting point:

129-131 °C(lit.)

Boiling point:

212-215 °C(lit.)

Density 

1.085

refractive index 

1.4248 (estimate)

Flash point:

212-215°C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

methanol: 0.1 g/mL, clear

form 

Crystals, Crystalline Powder and/or Chunks

pka

14.99±0.60(Predicted)

color 

White to off-white or slightly beige

PH

11.2 (4g/l, H2O, 20℃)

Water Solubility 

130 g/L (23 ºC)

BRN 

105039

InChIKey

VDVUCLWJZJHFAV-UHFFFAOYSA-N

CAS DataBase Reference

2403-88-5(CAS DataBase Reference)

NIST Chemistry Reference

4-Piperidinol, 2,2,6,6-tetramethyl-(2403-88-5)

EPA Substance Registry System

4-Piperidinol, 2,2,6,6-tetramethyl- (2403-88-5)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38-43-34

Safety Statements 

26-36-45-36/37/39

RIDADR 

UN3259 8/PG 2

WGK Germany 

1

RTECS 

TN7871675

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29333999

MSDS

• Language:English Provider:2,2,6,6-Tetramethyl-4-piperidinol
• Language:English Provider:SigmaAldrich
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2,2,6,6-Tetramethyl-4-piperidinol Usage And Synthesis

Chemical Properties

white to slightly beige crystalline powder

Uses

An intermediate in the preparation of Piperidinyloxy free radical derivatives.

Uses

2,2,6,6-tetramethyl-4-piperidinol has been used to study the irradiation of Camptothecin (CPT) in aerated dimethylsulfoxide (DMSO) solution that leads to formation of singlet oxygen.

Synthesis Reference(s)

The Journal of Organic Chemistry, 37, p. 2050, 1972 DOI: 10.1021/jo00977a047

Purification Methods

The piperidine crystallises from water as a hydrate and crystallises from dry ether or *C6H6 as the anhydrous base. The hydrochloride has m 282-284o (from EtOH/H2O), and the formate has m 207o(dec, from EtOH/EtOAc). [Mailey & Day J Org Chem 22 1061 1957, Beilstein 21 I 195, 21 III/IV 146, 21/1 V 159.]

2,2,6,6-Tetramethyl-4-piperidinol(2403-88-5)Related Product Information

• Haloperidol
• CHLOROPHOSPHONAZO III
• 2,2,6,6-Tetramethylpiperidinooxy
• Triacetonamine
• 2,2,6,6-Tetramethylpiperidine
• Triacetonediamine
• Leaf alcohol
• Tetrabutylammonium phosphate
• METHYL TETRAHYDROPYRAN-3-CARBOXYLATE
• Tetrabutylammonium hydrogen sulfate
• Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate
• N,N,N',N'-Tetramethylethylenediamine
• Tetrabutylammonium bromide
• Tri-(4-hydroxy-TEMPO) phosphite
• Tetramethylammonium hydroxide
• Tetramethylammonium hydroxide pentahydrate
• Tetramethylammonium chloride
• Tetramethylammonium nitrate