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(3,4-Dimethoxyphenyl)isopropyl ketone

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(3,4-Dimethoxyphenyl)isopropyl ketone Basic information

Product Name:
(3,4-Dimethoxyphenyl)isopropyl ketone
Synonyms:
  • (3,4-Dimethoxyphenyl)isopropyl ketone
  • 1-(3,4-Dimethoxyphenyl)-2-methyl-1-propanone
  • 3',4'-Dimethoxyisobutyrophenone
  • 1-Propanone, 1-(3,4-dimethoxyphenyl)-2-methyl-
  • Isobutyrophenone, 3',4'-dimethoxy-
  • Nsc63844
  • Verapamil Impurity 12(Verapamil EP Impurity L)
  • Verapamil Impurity L
CAS:
14046-55-0
MF:
C12H16O3
MW:
208.25
Mol File:
14046-55-0.mol
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(3,4-Dimethoxyphenyl)isopropyl ketone Chemical Properties

Boiling point:
165-170℃ (10 Torr)
Density 
1.029±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator, under inert atmosphere
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Oil
color 
Colourless
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(3,4-Dimethoxyphenyl)isopropyl ketone Usage And Synthesis

Uses

1-(3,4-Dimethoxyphenyl)-2-methyl-1-propanone (Verapamil EP Impurity L) is a compound being considered as an inhibitor of melanogenesis. It may reduce growth or pigment production in melanocyte cells.

Preparation

Preparation by acylation of veratrole,
with isobutyryl chloride in the presence of aluminium chloride (85%)
with isobutyric acid in the presence of PPA at 60° for 2.5 h
with isobutyric anhydride in acetonitrile in the presence of TiCl(OTf)3 /TfOH at r.t. for 12 h (89%).

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