Neochinulin A
Neochinulin A Basic information
- Product Name:
- Neochinulin A
- Synonyms:
-
- (3S)-3α-Methyl-6-[(Z)-[2-(1,1-dimethyl-2-propenyl)-1H-indole-3-yl]methylene]hexahydropyrazine-2,5-dione
- (6S)-3-[(Z)-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]methylene]-6-methyl-2,5-piperazinedione
- Neochinulin A
- Neoechinulin A
- 2,5-Piperazinedione, 3-[[2-(1,1-dimethyl-2-propen-1-yl)-1H-indol-3-yl]methylene]-6-methyl-, (3Z,6S)-
- (3S,6Z)-3-Methyl-6-{[2-(2-methyl-3-buten-2-yl)-1H-indol-3-yl]methylene}-2,5-piperazinedione
- (S,Z)-3-Methyl-6-((2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl)methylene)piperazine-2,5-dione
- CAS:
- 51551-29-2
- MF:
- C19H21N3O2
- MW:
- 323.39
- Mol File:
- 51551-29-2.mol
Neochinulin A Chemical Properties
- Melting point:
- 272-275 °C
- Boiling point:
- 655.7±55.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- 4°C, away from moisture and light
- form
- Solid
- pka
- 11.96±0.40(Predicted)
- color
- White to off-white
Neochinulin A Usage And Synthesis
Uses
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice[1][2].
in vivo
In the Y-maze test, the intracerebroventicular (i.c.v.) administration of LPS (10 μg/mouse) significantly decreased spontaneous alternation behavior, which was prevented by the prior administration of neoechinulin A (300ng/mouse, i.c.v.)[1].
References
[1] Humbert M, et al. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 2010;5(3):e9430. Published 2010 Mar 4. DOI:10.1371/journal.pone.0009430
[2] Kim KS, et al. Anti-inflammatory effect of neoechinulin a from the marine fungus Eurotium sp. SF-5989 through the suppression of NF-кB and p38 MAPK Pathways in lipopolysaccharide-stimulated RAW264.7 macrophages. Molecules. 2013;18(11):13245-13259. Publish DOI:10.3390/molecules181113245
[3] Dewapriya P, et al. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity. Neurotoxicology. 2013;35:30-40. DOI:10.1016/j.neuro.2012.12.004
Neochinulin ASupplier
- Tel
- 025-83697070
- info@chemlin.com.cn
- Tel
- 0871-65217109 13211707573;
- y.liu@mail.biobiopha.com
- Tel
- 0510-85629785 18013409632
- sales@reading-chemicals.com
- Tel
- 86-021-61559134 15921386130
- 3423497944@qq.com
- Tel
- 702-983-3769
- sales@albtechnology.com