Amentoflavone 4',4''',7''-trimethyl ether
Amentoflavone 4',4''',7''-trimethyl ether Basic information
- Product Name:
- Amentoflavone 4',4''',7''-trimethyl ether
- Synonyms:
-
- 2-(4-Methoxyphenyl)-5-hydroxy-7-methoxy-8-[2-methoxy-5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one
- 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
- Amentoflavone 4',4''',7''-trimethyl ether
- Kayaflavone
- 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-
- Amentoflavone 4',4''',7''-trimethyl ether USP/EP/BP
- CAS:
- 481-45-8
- MF:
- C33H24O10
- MW:
- 580.54
- Mol File:
- 481-45-8.mol
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Amentoflavone 4',4''',7''-trimethyl ether Chemical Properties
- Melting point:
- 314-315 °C (decomp)(Solv: methanol (67-56-1))
- Boiling point:
- 815.4±65.0 °C(Predicted)
- Density
- 1.445±0.06 g/cm3(Predicted)
- pka
- 6.00±0.40(Predicted)
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Amentoflavone 4',4''',7''-trimethyl ether Usage And Synthesis
Uses
Kayaflavone is an amentoflavone type biflavonoid. Kayaflavone has an inhibitory activity against amyloid-β42 cytotoxicity in PC-12 cells with an EC50 value of 5.29 μΜ. Kayaflavone is promising for research of Alzheimer’s disease[1].
References
[1] Sasaki H, et al. Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2831-3. DOI:10.1016/j.bmcl.2015.04.106
[2] Sun CM, et al. Selective cytotoxicity of ginkgetin from Selaginella moellendorffii. J Nat Prod. 1997 Apr;60(4):382-4. DOI:10.1021/np960608e
Amentoflavone 4',4''',7''-trimethyl etherSupplier
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