3-Hydroxy-2-naphthalenecarboxylic acid ethyl ester Chemical Properties

Melting point:

79.0 to 83.0 °C

Boiling point:

291°C(lit.)

Density 

1.1652 (rough estimate)

refractive index 

1.5090 (estimate)

solubility 

soluble in Toluene

form 

powder to crystal

pka

9.53±0.40(Predicted)

color 

White to Orange to Green

Safety Information

HS Code 

2918290090

3-Hydroxy-2-naphthalenecarboxylic acid ethyl ester Usage And Synthesis

Uses

3-Hydroxy-2-naphthalenecarboxylic acid ethyl ester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

To a round bottom flask were added 5 g 3-hydroxy-2-naphthalic acidand 16 mL ethanol. The reaction mixture was refluxed for 6 h. After thecompletion of the reaction, the reaction mixture was cooled down to room temperature and washed with distilled water. The organic layerwas recovered and washed with saturated sodium bicarbonate followedby drying with anhydrous MgSO4. The MgSO4 was removed by filtrationand the filtrate was dried under reduced pressure. The resulted solid waspurified by silica chromatography with petroleum ether and ethyl acetate(10:1, v/v) as eluent to give the compound ethyl 3-hydroxy-2-naphthoate(4.1229 g, yield 70.60%).