4-(Pyridin-3-yl)pyrimidin-2-amine Chemical Properties

Melting point:

189-191 °C

Boiling point:

439.9±37.0 °C(Predicted)

Density 

1.259±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

2.76±0.10(Predicted)

color 

Off-White to Pale Yellow

InChI

InChI=1S/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13)

InChIKey

LQHQKYWYKPLKCH-UHFFFAOYSA-N

SMILES

C1(N)=NC=CC(C2=CC=CN=C2)=N1

Safety Information

Hazard Codes 

T

Risk Statements 

25-20/21/22

Safety Statements 

45-36/37

HS Code 

29339900

4-(Pyridin-3-yl)pyrimidin-2-amine Usage And Synthesis

Chemical Properties

White to off-white or brown solid.

Uses

4-(3-Pyridinyl)-2-pyrimidinamine serves as an intermediate compound during the synthesis of Nilotinib. Nilotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of chronic myelogenous leukemia.

Synthesis

3-(Dimethylamino)-1-(pyridine-3-yl) prop-2-en-1-one (15.4 g, 0.088 mol), guanidine nitrate (10.7 g, 0.088 mol), and sodium hydroxide (3.5 g, 0.088 mol) were dissolved in n-butanol (120 mL). The mixture was heated to reflux with stirring and maintained for 16 hours. The reaction mixture was then cooled to room temperature. The solid was collected and washed with water (400 mL). The desired product was dried under vacuum for three days, and 12.7 g of yellow crystals of 4-(Pyridin-3-yl)pyrimidin-2-amine was obtained (yield: 85 %).

4-(Pyridin-3-yl)pyrimidin-2-amine(66521-66-2)Related Product Information

• 2-Aminopyrimidine
• 3-Aminopyridine
• Molasses
• 2-Aminopyridine
• 4-Dimethylaminopyridine
• Nilotinib N-Oxide
• Nilotinib Impurity 4
• Benzenamine, 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-
• Nilotinib
• 3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine
• 3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide
• 3-(2,4-dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-Benzenamine
• N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
• N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
• Imatinib
• N-Desmethyl Imatinib
• 2-METHYL-N1-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-1,4-BENZENEDIAMINE
• 4-METHYL-6-PYRIDIN-3-YLPYRIMIDIN-2-AMINE