4-Pyridylcarbinol Chemical Properties

Melting point:

52-56 °C (lit.)

Boiling point:

107-110 °C/1 mmHg (lit.)

Density 

1.1143 (rough estimate)

refractive index 

1.5040 (estimate)

Flash point:

>230 °F

storage temp. 

2-8°C

pka

13.45±0.10(Predicted)

form 

Crystals, Crystalline Powder or Crystalline Mass

color 

White to yellow

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

107850

InChI

1S/C6H7NO/c8-5-6-1-3-7-4-2-6/h1-4,8H,5H2

InChIKey

PTMBWNZJOQBTBK-UHFFFAOYSA-N

SMILES

OCc1ccncc1

LogP

0.060

CAS DataBase Reference

586-95-8(CAS DataBase Reference)

NIST Chemistry Reference

4-Pyridinemethanol(586-95-8)

EPA Substance Registry System

4-Pyridinemethanol (586-95-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-22

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

UT4691000

F 

10-21

Hazard Note 

Irritant

TSCA 

TSCA listed

HazardClass 

IRRITANT, HYGROSCOPIC, KEEP COLD

HS Code 

29333999

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2

MSDS

• Language:English Provider:4-(Hydroxymethyl)pyridine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Pyridylcarbinol Usage And Synthesis

Chemical Properties

white to yellow crystals, crystalline powder or

Uses

4-Pyridylcarbinol can be used in the preparation of 4-pyridine carboxaldehyde.

Synthesis

(a) said 4-methylpyridine is reacted with glacial acetic acid and hydrogen peroxide at a reaction temperature of 70?? C. and a reaction time of 14h, and the molar ratio of said 4-methylpyridine, glacial acetic acid, and hydrogen peroxide is 1:3.5:3, to obtain 4-pyridine nitride;

(b) said 4-pyridine nitride is reacted with acetic anhydride at a reaction temperature of 85?? C. and a reaction time of 6h, and the molar ratio of said 4- pyridine nitrogen oxide and acetic anhydride at a molar ratio of 1:2.5 to obtain 4-pyridine methyl acetate;

(c) said 4-pyridine methyl acetate reacted with potassium hydroxide solution at a reaction time of 4h,said 2-pyridine methyl acetate reacted with potassium hydroxide at a molar ratio of 1:1.5 to obtain 4-pyridine methanol.

4-Pyridylcarbinol(586-95-8)Related Product Information

• 3-Aminopyridine
• Sulfasalazine
• 4-Methylpyridine
• Chromium picolinate
• Pyridine
• Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• Donepezil
• XWAIAVWHZJNZQQ-RPXFAUAJSA-N
• 5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one
• 5-O-Desmethyl Donepezil
• 2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE
• Dihydro Donepezil (Mixture of Diastereomers)
• Donepezil Impurity
• Donepezil Impurity
• 3,5-Dichloro-4-hydroxypyridine
• 5-Hydroxy-6-methoxy-1-indanone
• 3,4-Dimethoxyhydrocinnamic acid
• Donepezil Impurity-OH