FMRF AMIDE
FMRF AMIDE Basic information
- Product Name:
- FMRF AMIDE
- Synonyms:
-
- PHE-MET-ARG-PHE AMIDE
- PHE-MET-ARG-PHE-NH2
- PHE-MET-ARG-PHE-NH2 1/2ACOH 2H2O
- MOLLUSCAN CARDIOEXCITATORY PEPTIDE
- MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE
- MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE 1 1/2 ACOH 2H2O
- MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE ACETATE SALT
- H-PHE-MET-ARG-PHE-NH2
- CAS:
- 152165-14-5
- MF:
- C29H42N8O4S
- MW:
- 598.76
- Product Categories:
-
- Peptide
- Mol File:
- 152165-14-5.mol
FMRF AMIDE Chemical Properties
- storage temp.
- −20°C
- Sequence
- Phe-Met-Arg-Phe-NH2
MSDS
- Language:English Provider:SigmaAldrich
FMRF AMIDE Usage And Synthesis
Uses
Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons[1].
in vivo
Phe-Met-Arg-Phe, amide (FMRFamide) acetate stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 pM) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 pM) of FMRFamide is already developed after 5 min and lasted up to 30 min[3].
References
[1] Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. DOI:10.1085/jgp.110.5.611
[2] Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. DOI:10.1016/0196-9781(84)90021-4
[3] Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7. DOI:10.1016/0143-4179(87)90054-0
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FMRF AMIDE(152165-14-5)Related Product Information
- FMRF-AMIDE LIKE PEPTIDE 1 (LOBSTER),FMRF AMIDE-LIKE PEPTIDE I, LOBSTER
- FMRF amide (Nle-Arg-Phe-NH2)
- FMRF amide (Phe-Met-Arg-Phe)
- FMRF amide-like Peptide II (lobster) (Thr-Asn-Arg-Asn-Phe-Leu-Arg-Phe-NH2)
- FMRF amide (Tyr-Phe-Met-Arg-Phe-NH2)
- FMRF amide (Ac-Phe-Nle-Arg-Phe-NH2)
- FMRF amide (Phe-Met-Arg-Phe-NH2) (Molluscan Cardioexcitatory Neuropeptide)
- FMRF amide (AF-2) (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2)
- FMRF amide (AF-1) (Lys-Asn-Glu-Phe-Ile-Arg-Phe-NH2)
- FMRF amide (Phe-Leu-Arg-Arg)
- H-TYR-PHE-MET-ARG-PHE-NH2
- [D-MET2]-FMRF-AMIDE
- FMRF amide (Trp-Nle-Arg-Phe-NH2)
- FMRF amide (Met-Arg-Phe)
- H-TYR-GLY-GLY-PHE-MET-ARG-PHE-NH2
- TYR-MET-ARG-PHE-NH2
- FMRF AMIDE
- FMRF amide [D-Phe4] (Phe-Met-Arg-D-Phe-NH2)