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Indigo Carmine

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Indigo Carmine Basic information

Product Name:
Indigo Carmine
Synonyms:
  • Indigo Carmine,for analysis,high purity biological stain
  • Indigo Carmine,pure,certified
  • Indigo carmine, C.I. 73015, extra pure
  • Indigo carmine 1g [860-22-0]
  • FD & C Blue 2
  • Indigotindisulfonate Sodium (500 mg)
  • INDIGOCARMINE, REAG
  • Indigo carMine sodiuM salt
CAS:
860-22-0
MF:
C16H8N2Na2O8S2
MW:
466.35
EINECS:
212-728-8
Product Categories:
  • Analytical Chemistry
  • Food Colors by Food Sanitation Law in Japan
  • Indicator (pH)
  • pH Indicators
  • Indicator SolutionsTitration
  • Indicators
  • Redox Indicators
  • Titration
  • Indole
  • Indigoid
  • Miscellaneous
Mol File:
860-22-0.mol
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Indigo Carmine Chemical Properties

Melting point:
>300°C
Density 
1.01 g/mL at 20 °C
refractive index 
n20/D 1.335
storage temp. 
Store below +30°C.
solubility 
1g/l
form 
Powder/Solid
Colour Index 
73015
color 
Very dark blue to purple
Odor
Light odour
PH
7 (10g/l, H2O, 20℃)
PH Range
11.5(blue)-14.0(yellow)
Water Solubility 
1 g/100 mL (25 ºC)
λmax
608nm
Sensitive 
Light Sensitive
Merck 
14,4944
BRN 
4103904
Stability:
Stable. Incompatible with strong oxidizing agents.
Biological Applications
Detecting microorganisms; treating amyloidosis,testicular cancer; medical devices; drug delivery system
Major Application
Display device, sensor, chemical-mechanical polishing, batteries, photographic materials, thermoplastics, inks, highlighters, detergents, disinfectants, rodenticide, colored bubbles, hair dyes, cosmetics, food, determine bacterial growth, antiischemic Magents, antiseptic, antitumor agents, Alzheimer’s disease, psychoactive drugs, Tooth whitening
CAS DataBase Reference
860-22-0(CAS DataBase Reference)
EPA Substance Registry System
C.I. Acid Blue 74 (860-22-0)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
22-24/25-36/37/39-27-26
WGK Germany 
3
RTECS 
DU3000000
TSCA 
Yes
HS Code 
32041200
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg

MSDS

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Indigo Carmine Usage And Synthesis

Description

Indigo carmine is indigotindisulfonate sodium, a marker dye used during cystoscopy and ureteral catheterization.
(1) Indigo carmine is also used in endoscopic procedures, lymph node and vessel delineation, and for tumor localization. Indigo carmine is an unapproved drug without FDA approved labeling.
(2) There is no single dye that can replace indigo carmine. Choice of alternative agent will depend on type of procedure and physician discretion, as well as product availability.
Indigo Carmine (IC) is the most common chemical dye for clothes dyeing, which is considered as a refractory molecule since it is required a rather strong chemical treatment for its elimination from the water waste. The presence of this dye in residuals causes notorious change of water color and smell even in very low concentration. Moreover, if some of this water reaches natural streams it can be toxic for aquatic living entities due to the formation of toxic compounds such as aromatic amines.

Chemical Properties

purple powder

Chemical Properties

FD & C Blue No. 2 is principally the disodium salt of 2-( 1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro3-oxo-lH-indole-5-sulfonic acid.
The colorant is a blue-brown to red-brown powder that dissolves in water to give a solution that is blue at neutrality, blue-violet in acid, and green to yellow-green in base. When dissolved in concentrated sulfuric acid, it yields a blue-violet solution that turns blue when diluted with water. It is soluble in 95% ethanol.
FD & C Blue No. 2 is used in dessert powders, bakery goods, cereals, snack foods, confectionery products, maraschino cherries, sausage, ice cream, sherbet, and dairy products. The color is also used in drug preparations.1 .

Uses

Colorant for nylon, surgical sutures, foods and ingested drugs. As a reagent for functional kidney tests, for detection of nitrates, chlorates and in testing milk.

Uses

Indigo Carmine (FD&C Blue #2) is a colorant. It has poor ph stability in that after 1 week at ph 3 and 5 it will appreciably fade, at ph 7 considerably fade, and at ph 8 fade completely. It is the least soluble of all food colors, with a solubility of 1.6 g in 100 ml of water at 25°c. Complete fading occurs in alkalis such as 10% sodium carbonate and 10% sodium hydroxide, with fading also occurring in 10% sugar systems. It has very poor light stability and oxidation stability, and moderate stability to heat; it has a deep blue hue with poor tinctorial strength. It is the only food color that has good resistance to reducing agents, but has very poor compatibility with food components. The major use is in pet food, but it is also used in candies, confections, and baked goods. The common name is indigotine.

Uses

5,5’Indigodisulfonic Acid Disodium Salt is a food additive that is widely used in the market. 5,5’Indigodisulfonic Acid Disodium Salt was also used as a dye for cationic cotton fabrics.

Definition

ChEBI: An organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. It is an indicator at pH 11.5-14, changing from blue to yellow.

brand name

Indigo Carmine (Becton Dickinson Microbiology).

General Description

Indigo to dark blue powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Sensitive to light. Very sensitive to oxidizing agents. Color is readily discharged by nitric acid, chlorates, etc. Color of aqueous solutions fades on standing.

Fire Hazard

Flash point data for Acid Blue 74 is not available, but Acid Blue 74 is probably combustible.

Purification Methods

Its solubility in H2O is 1g/100mL at 25o. It has been purified by dissolving in H2O, filtering and adding EtOH to cause the salt to separate. Wash the solid with EtOH, Et2O and dry in vacuo. [V.rlander & Schubert Chem Ber 34 1860 1901, UV: Smit et al. Anal Chem 27 1159 1955, Preisler et al. J Am Chem Soc 81 1991 1959, Beilstein 25 IV 1975.]

References

American Society of Health-system Pharmacist.
Journal of Environmental Protection, 2016, 7, 1693-1706

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