6-Methoxyquinoline Chemical Properties

Melting point:

18-20 °C (lit.)

Boiling point:

140-146 °C/15 mmHg (lit.)

Density 

1.15 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.625(lit.)

FEMA 

4640 | 6-METHOXYQUINOLINE

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

soluble in Alcohol

pka

5.03(at 20℃)

form 

Granular Powder

color 

White to cream

Odor

heavy sweet

Water Solubility 

insoluble

Sensitive 

Light Sensitive

JECFA Number

2157

BRN 

115244

LogP

2.17

CAS DataBase Reference

5263-87-6(CAS DataBase Reference)

NIST Chemistry Reference

Quinoline, 6-methoxy-(5263-87-6)

EPA Substance Registry System

Quinoline, 6-methoxy- (5263-87-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

23-24/25-36-26

WGK Germany 

3

F 

8

TSCA 

Yes

HS Code 

29334990

MSDS

• Language:English Provider:6-Methoxyquinoline
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

6-Methoxyquinoline Usage And Synthesis

Chemical Properties

colorless to light yellow liquid

Uses

6-Methoxyquinoline is used as a precursor in the synthesis of:

• Fluorescent zinc and chlorine sensors.
• 5-Amino-2-aroylquinolines as potent tubulin polymerization inhibitors.
• 3-Fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase.
• Cobalt-based ternary metal-organic complex as single?ion magnets.

Uses

6-Methoxyquinoline is a useful sythetic intermediate

Definition

ChEBI: An aromatic ether that is quinoline substituted at position 6 by a methoxy group.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1584, 1946 DOI: 10.1021/ja01212a062

6-Methoxyquinoline(5263-87-6)Related Product Information

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• 8-(4-AMINO-1-METHYLBUTYLAMINO)-6-METHOXYQUINOLINE DIPHOSPHATE
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• 2-METHYL-6-ETHOXYQUINOLINE
• 4-chloro-6,7-dimethoxyquinoline
• 2-CHLORO-6-METHOXY-QUINOLINE
• 4-HYDROXY-7-METHOXY-1H-QUINOLIN-2-ONE
• ethyl 4-hydroxy-5,6,8-trimethoxyquinoline-2-carboxylate
• 2-Methoxyquinoline-3-boronic acid
• 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID
• 2(1H)-Quinoxalinone,3-amino-5-methoxy-(9CI)