SINENSETIN
SINENSETIN Basic information
- Product Name:
- SINENSETIN
- Synonyms:
-
- Orange flavonoids
- 6-Hydroxyluteolin 5,6,7,3′,4′-pentamethyl ether
- SINENSETIN
- 3',4',5,6,7-PENTAMETHOXYFLAVONE
- 5,6,7,3',4'-PENTAMETHOXYFLAVONE
- 5,6,7,3'',4''-PENTAMETHOXYFLAVONE WITH HPLC
- 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one
- Pedalitin permethyl ether
- CAS:
- 2306-27-6
- MF:
- C20H20O7
- MW:
- 372.37
- Product Categories:
-
- Penta-substituted Flavones
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 2306-27-6.mol
SINENSETIN Chemical Properties
- Melting point:
- 174-176°C
- Boiling point:
- 547.8±50.0 °C(Predicted)
- Density
- 1.244±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble3mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
- BRN
- 345748
- LogP
- 2.634 (est)
- CAS DataBase Reference
- 2306-27-6(CAS DataBase Reference)
Safety Information
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 22-24/25-45
- WGK Germany
- 3
- HS Code
- 29329990
SINENSETIN Usage And Synthesis
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from citrus.
Uses
antiangiogenesis, antidiabetic
Uses
Sinensetin, eupatorin, 3'-hydroxy-5,6,7,4'-tetramethoxyflavone and rosmarinic acid contents and antioxidative effect of Orthosiphon stamineus from Malaysia.
Uses
Sinensetin exhibits anti-fungal, anti-histamine activity; induce cell differentiation, inhibition of linoleic acid oxidation, inhibition of white blood cells in the human zona protein Interleukin -1-i nduced expression of tissue factor.
Definition
ChEBI: A pentamethoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 3' and 4' respectively.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Sinensetin is a citris flavonoid with anti-inflammatory and anti-proliferative activity. It has also been shown to enhance adipogenesis and lipolysis.
in vivo
Sinensetin (50 mg/kg, single dose, i.p.) has anti-inflammatory effects on carrageenan (HY-125474) induced paw inflammation in the mouse[5].
| Animal Model: | Carrageenan-induced paw edema in male C57BL/6 mice[5] |
| Dosage: | 50 mg/kg, single dose |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Sloewd the volume increased of the carrageenan-treated paw at 6 h. |
SINENSETINSupplier
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 025-83697070
- info@chemlin.com.cn
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 400-1166-196 18981987031
- cdhxsj@163.com
- Tel
- +86-0755-89668383
- sales@sungening.com
SINENSETIN(2306-27-6)Related Product Information
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- Glycitin
- (1S,2S,6S,9R)-9-hydroxy-9-(hydroxymethyl)-2-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,7-diene-5-carboxylic acid
- CARNOSOL
- CYCLOPAMINE
- Lobetyolin
- Evodine
- Pachymic acid
- (-)-Arctigenin
- Polygalacic acid
- Parthenolide
- 5-HYDROXYFLAVONE
- 5,7,8-TRIHYDROXYFLAVONE
- SINENSETIN(P),SINENSETIN(SH)
- 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE
- 3',4',5',5,6,7-HEXAMETHOXYFLAVONE
- SINENSETIN
- 3,3',4',5,6,7,8-heptamethoxyflavone