1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE Chemical Properties

Boiling point:

572.5±50.0 °C(Predicted)

Density 

1.60±0.1 g/cm3(Predicted)

storage temp. 

-10 to -25°C

solubility 

DMSO: 2mg/mL, clear

form 

Solid

pka

14.01±0.60(Predicted)

color 

Light yellow to yellow

1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE Usage And Synthesis

Uses

5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide (HY-17364). 5-NIdR induces cancer cells apoptosis and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model[1].

in vivo

References

[1] Choi JS, et al. Inhibition of Translesion DNA Synthesis as a Novel Therapeutic Strategy to Treat Brain Cancer. Cancer Res. 2018 Feb 15;78(4):1083-1096. DOI:10.1158/0008-5472.CAN-17-2464

1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE(191421-10-0)Related Product Information

• 2'-DEOXYGUANOSINE5'-MONOPHOSPHATE,DISODIUM SALT(DGMP·2NA)
• 5-Nitroindole
• 1-(5-O-(DIMETHOXYTRITYL)-BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE
• 5-NITRO-1-INDOLYL-2'-DEOXYRIBOSE-5'-TRIPHOSPHATE LITHIUM SALT
• 1-METHYL-5-NITRO-1H-INDOLE
• 1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-NITROINDOLE