(+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione Usage And Synthesis

Uses

Yadanziolide B, a natural quassinoid, is a potential H5N1 neuraminidase inhibitor[1][2].

Definition

ChEBI: Yadanziolide B is a quassinoid that is 13,20-epoxypicras-3-ene substituted by hydroxy groups at positions 1, 6, 11, 12, 14, 15 and 21 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity. It has a role as an antineoplastic agent and a plant metabolite. It is a quassinoid, a delta-lactone, an enone, an organic heteropentacyclic compound, a heptol and a secondary alpha-hydroxy ketone. It derives from a hydride of a picrasane.

References

[1] Hui Chen, et al. Indole alkaloids and quassinoids from the stems of Brucea mollis. J Nat Prod. 2011 Nov 28;74(11):2438-45. DOI:10.1021/np200712y
[2] Rina Fajri Nuwarda, et al. Molecular Docking Studies of Compounds from Brucea javanica (L.) Merr. Towards The Discovery of Potential H5N1 Neuraminidase Inhibitors. Beranda Vol 7, No 1 (2020) Nuwarda.

(+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione(95258-13-2)Related Product Information

• Picras-3-en-21-oicacid,15-[[(2E)-4-(acetyloxy)-3,4-dimethyl-1-oxo-2-pentenyl]oxy]-13,20-epoxy-3-(b-D-glucopyranosyloxy)-11,12-dihydroxy-2,16-dioxo-,methyl ester, (11b,12a,15b)- (9CI)
• (-)-13,20-Epoxy-1β,11β,12α,14,15β,21-hexahydroxypicrasa-3-ene-2,16-dione
• brusatol
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• DEHYDROBRUCEANTIN
• bruceine A
• bruceine E
• bruceine D
• YADANZIOLIDE-C
• yadanziolide A
• yadanzioside M
• YADANZIOSIDE-G
• yadanzioside F
• bruceantinoside B
• Yadanzioside I
• YADANZIOSIDE-L
• YADANZIOSIDE-C
• bruceine B