Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione Chemical Properties

Melting point:

320 °C

Density 

1.424±0.06 g/cm3(Predicted)

pka

9.27±0.20(Predicted)

Safety Information

HS Code 

2933998090

Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione Usage And Synthesis

Uses

2,4-Dihydroxypyrido[3,2-d]pyrimidine is used as a reagent in the synthesis of diaminoquinazolines as antitubercular agents. 2,4-Dihydroxypyrido[3,2-d]pyrimidine may also be used as a potential histamine H4 receptor antagonist.

Synthesis

(1) 4 g of 3-aminopyridine-2-carboxylic acid (raw material A3) was mixed with 20 g of urea and heated and refluxed at 200°C for 5 h. After the reaction was completed, intermediate B3 was obtained in 27% yield. The reaction equation was as follows:

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 9, p. 2663 - 2670
[2] Patent: CN106083742, 2016, A. Location in patent: Paragraph 0185; 0186; 0187
[3] Journal of the Chemical Society, 1956, p. 1045,1053

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