1-BROMO-4-(2,2,2-TRIFLUOROETHOXY)BENZENE Chemical Properties

Boiling point:

212.8±40.0 °C(Predicted)

Density 

1.569±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid

InChI

InChI=1S/C8H6BrF3O/c9-6-1-3-7(4-2-6)13-5-8(10,11)12/h1-4H,5H2

InChIKey

SMDIDUHBHCDCRQ-UHFFFAOYSA-N

SMILES

C1(Br)=CC=C(OCC(F)(F)F)C=C1

Safety Information

HS Code 

2909309090

1-BROMO-4-(2,2,2-TRIFLUOROETHOXY)BENZENE Usage And Synthesis

Synthesis

General procedure for the synthesis of 1-bromo-4-(2,2,2-trifluoroethoxy)benzene from 4-bromophenol and 2,2,2-trifluoroethyl trifluoromethanesulfonate: first, 4-bromophenol (9.57 g, 55 mmol) was dissolved in acetone (200 mL), followed by the addition of potassium carbonate (22.89 g, 166 mmol) and 2,2,2-trifluoroethyl trifluoromethanesulfonate ester (16.0 g, 69 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was filtered to remove the insoluble salt and then concentrated under reduced pressure at 300 mbar at 30 °C to remove the acetone. The final product was 1-bromo-4-(2,2,2-trifluoroethoxy)benzene as a waxy solid (more than 100% yield, as a small amount of acetone remained in the product).

References

[1] Patent: WO2005/822, 2005, A1. Location in patent: Page/Page column 44
[2] Patent: US2016/332999, 2016, A1. Location in patent: Paragraph 0576; 0577

1-BROMO-4-(2,2,2-TRIFLUOROETHOXY)BENZENE(106854-77-7)Related Product Information

• 5-bromo-2-(2,2,2-trifluoroethoxy)aniline
• RARECHEM AL BO 0707
• 1-BROMO-4-(2,2,2-TRIFLUOROETHOXY)BENZENE
• 2-Adamantyl-4-bromo-1-(2,2,2-trifluoroethoxy)benzene
• 2,6-BIS(2,2,2-TRIFLUOROETHOXY)-3-BROMOBENZONITRILE
• 2-(4-BROMO-PHENOXY)-3,3,3-TRIFLUORO-PROPYLAMINE
• RARECHEM AL BW 0738