1-(Tetrahydro-2-furoyl)piperazine Chemical Properties

Boiling point:

140 °C (1.5002 mmHg)

Density 

1.17

refractive index 

1.5195-1.5215

Flash point:

120-125°C/0.2mm

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Viscous Liquid

pka

8.37±0.10(Predicted)

color 

Colorless to yellow

Water Solubility 

Fully miscible in water.

BRN 

880578

InChI

1S/C9H16N2O2/c12-9(8-2-1-7-13-8)11-5-3-10-4-6-11/h8,10H,1-7H2

InChIKey

UKESBLFBQANJHH-UHFFFAOYSA-N

SMILES

O=C(C1CCCO1)N2CCNCC2

CAS DataBase Reference

63074-07-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36

Safety Statements 

37/39-26-37

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29349990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-(Tetrahydro-2-furoyl)piperazine Usage And Synthesis

Chemical Properties

colorless to yellow viscous liquid

Uses

1-?(Tetrahydro-?2-?furoyl)?-?piperazine (Terazosin EP Impurity N) has been used as a reactant for the preparation of pyrazol-3-propanoic acid derivatives as inhibitors of leukotriene biosynthesis in human neutrophils.

Definition

ChEBI: 1-(Tetrahydro-2-furoyl)piperazine is a member of phytanoyl-CoAs.

Synthesis

1-(Tetrahydro-2-furoyl)piperazine was prepared by using tetrahydrofurfuryl alcohol as the starting material, and the target compound tetrahydrofurfuryl piperazine was prepared by oxidizing tetrahydrofurfuryl acid, chlorinating to prepare acyl chloride and then acylating with piperazine.

1-(Tetrahydro-2-furoyl)piperazine(63074-07-7)Related Product Information

• [4-(4-AMino-7-hydroxy-6-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone
• Terazosin EP IMpurity D
• [4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl][(5S)-tetrahydro-5-Methyl-2-furanyl]Methanone
• [4-(4-AMino-6-hydroxy-7-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone
• Terazosin IMpurity J
• 2-Piperazine-4-amino-6,7-dimethoxyquinazoline
• Terazosin impurity
• (R)-Terazosin
• 2,2'-(1,4-Piperazinediyl)bis[6,7-diMethoxy-4-quinazolinaMine]
• 1-[4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl]-5-hydroxy-1-pentanone
• 6,7-DiMethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one
• NSC 351869
• 1-(2-Furoyl)piperazine
• Terazosin hydrochloride dihydrate
• Piperazine, 1-[[(2R)-tetrahydro-2-furanyl]carbonyl]- (9CI)
• Prazosin hydrochloride
• Terazosin EP Impurity O
• 2-Chloro-4-amino-6,7-dimethoxyquinazoline