ZANAPEZIL
ZANAPEZIL Basic information
- Product Name:
- ZANAPEZIL
- Synonyms:
-
- ZANAPEZIL
- 1-Propanone, 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-
- TAK-147 free base
- Zanapezil free base
- CAS:
- 142852-50-4
- MF:
- C25H32N2O
- MW:
- 376.53
- Mol File:
- 142852-50-4.mol
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ZANAPEZIL Chemical Properties
- form
- Solid
- color
- White to light yellow
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ZANAPEZIL Usage And Synthesis
Uses
Zanapezil is a acetylcholinesterase inhibitor that is a potential drug for treating Alzheimer disease.
Definition
ChEBI: Zanapezil is a member of piperidines.
in vivo
Oral administration of Zanapezil (TAK-147; 3 mg/kg) free base significantly accelerated the turnover rates of dopamine, noradrenaline and serotonin in the rat brain. Oral administration of Zanapezil free base at doses ranging from 1 to 10 mg/kg induces a statistically significant and dose-dependent decrease in AChE activity in the cerebral cortex in ex vivo experiments[1].
Zanapezil (TAK-147; 5 and 10 mg/kg) free base significantly increases ACh level in the ventral hippocampus (VH) for 120 min[2].
| Animal Model: | Male Wistar rats 7 weeks in age (230-240 g)[2] |
| Dosage: | 5 and 10 mg/kg |
| Administration: | Oral administration |
| Result: | Increased acetylcholine (ACh) level in the VH for 120 min. |
IC 50
AChE
ZANAPEZILSupplier
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
- Tel
- 18818260767
- sales@chemegen.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com
Shanghai Tachizaki Biomedical Research Center
- Tel
- 18014399201
- sales@chemlab-tachizaki.com
Biosynth Biological Technology (Suzhou) Co Ltd
- Tel
- 51288865780
- sales@biosynth.com