1-BOC-6-BROMO-INDAZOLE Chemical Properties

Boiling point:

377℃

Density 

1.46

Flash point:

182℃

storage temp. 

2-8°C

form 

solid

color 

White

Safety Information

HS Code 

2933998090

1-BOC-6-BROMO-INDAZOLE Usage And Synthesis

Synthesis

a) A suspension of 6-bromo-1H-indazole (82.74 mmol), 4-dimethylaminopyridine (DMAP, 16.55 mmol), and triethylamine (Et3N, 19.56 mL) in acetonitrile (CH3CN) was slowly added to an acetonitrile solution of di-tert-butyl dicarbonate (82.74 mmol) over a period of 15 min at 0°C, keeping the internal temperature no more than 5°C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 18 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by fast column chromatography (eluent: 7% ethyl acetate/petroleum ether) to afford tert-butyl 6-bromo-1H-indazole-1-carboxylate (23.2 g, 94% yield) as a white solid.

References

[1] Patent: WO2012/37298, 2012, A1. Location in patent: Page/Page column 49
[2] Patent: WO2013/28445, 2013, A1. Location in patent: Page/Page column 54; 55
[3] Patent: WO2011/66211, 2011, A1. Location in patent: Page/Page column 71-72
[4] Patent: WO2016/57834, 2016, A1. Location in patent: Paragraph 000198

1-BOC-6-BROMO-INDAZOLE(877264-77-2)Related Product Information

• Benzoic acid, 6-bromo-2,3-dichloro-, 1,1-dimethylethyl ester
• tert-butyl 6-bromo-2,3-dichloroisonicotinate
• 1H-Indazole-3-carboxylic acid, 6-broMo-, 1,1-diMethylethyl ester
• 1-BOC-6-AMINO-INDAZOLE