7-BROMOQUINOLIN-2(1H)-ONE Chemical Properties

Melting point:

270-272℃

Boiling point:

375.4±42.0 °C(Predicted)

Density 

1.620

storage temp. 

Inert atmosphere,Room Temperature

pka

10.91±0.70(Predicted)

Appearance

Off-white to light brown Solid

7-BROMOQUINOLIN-2(1H)-ONE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 7-bromo-2-chloroquinolin-2(1H)-one from 7-bromo-2-chloroquinoline was as follows: 7-bromo-2-chloroquinoline (5.0 g, 20.6 mmol) was dissolved in a mixed solvent of 5 M aqueous hydrochloric acid (133 mL) and 1,4-dioxane (14 mL) with stirring and heated to reflux for 2 hours. After completion of the reaction, it was cooled to room temperature, the precipitate precipitated was collected by filtration and washed with deionized water to afford 7-bromoquinolin-2(1H)-one as a colorless solid (4.3 g, 93% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 11.80 (s, 1H), 7.91 (d, J=8.0 Hz, 1H), 7.63 (d, J=8.0 Hz, 1H), 7.48 (d, J=8.0 Hz, 1H), 7.34 (dd, J=8.0, 4.0 Hz, 1H), 6.53 (d, J= 4.0 Hz, 1H).

References

[1] Patent: US2015/210655, 2015, A1. Location in patent: Paragraph 0291
[2] Patent: US9522894, 2016, B2. Location in patent: Page/Page column 34
[3] Patent: WO2008/71961, 2008, A1. Location in patent: Page/Page column 103-104
[4] Patent: WO2006/134378, 2006, A1. Location in patent: Page/Page column 61-62

7-BROMOQUINOLIN-2(1H)-ONE(99465-10-8)Related Product Information

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• 1H-INDAZOLE, 5-BROMO-3-(TRIFLUOROMETHYL)-
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• 7-BROMOQUINOLIN-2(1H)-ONE