PPT Chemical Properties

Melting point:

230 °C (decomp)

Boiling point:

630.0±55.0 °C(Predicted)

Density 

1.24±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 20 mg/mL, soluble

form 

solid

pka

8.80±0.15(Predicted)

color 

off-white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

PPT Usage And Synthesis

Uses

PPT is a potent and specific ERα agonist.

Definition

ChEBI: 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol is a pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. It has a role as an estrogen receptor agonist. It is a member of pyrazoles and a member of phenols.

General Description

Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons.

Biological Activity

Potent, subtype-selective estrogen receptor agonist (EC 50 ~ 200 pM); displays 410-fold selectivity for ER α over ER β . Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo .

Biochem/physiol Actions

Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.

storage

+4°C

PPT(263717-53-9)Related Product Information

• Pyridinium p-Toluenesulfonate
• IGG, DIFFERENTIAL PPT, RABBIT
• PPT
• Barium sulfate
• Protopanaxatriol
• PPT
• 4''-PHOSPHOPANTETHEINE (PPT)
• Monoclonal Anti-Human IgG, Gel ppt. (γ-chain specific) antibody produced in mouse
• PPT,3-(4-PHENYL-2-PYRIDYL)-5-PHENYL-1,2,4-TRIAZINE (PPT)
• PPT-901
• IGG, DIFFERENTIAL PPT, MOUSE
• ESTRADIOL-17SS,ELISAKIT(DETECTION:20PPT)
• DES (Diethylstilbestrol), ELISA KIT (detection: 200 ppt)
• ANTI-PPT
• STAPHYLOCOCCUSAUREUSENTEROTOXINS(SET)A,B,C,D,E,ELISAKIT(DETECTION:100PPT)
• PPT protein
• IGG Γ CHAIN, ANTI-HUMAN, (GG-4MAB), LQ (GEL PPT)
• CHLORAMPHENICOL,ELISAKIT(DETECTION:100PPT)