2,3-dimethyl-6-nitro-2H-indazole Chemical Properties

Melting point:

183-186°C

Boiling point:

377.0±22.0 °C(Predicted)

Density 

1.36±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

-0.55±0.30(Predicted)

form 

Solid

color 

Yellow

2,3-dimethyl-6-nitro-2H-indazole Usage And Synthesis

Uses

2,3-Dimethyl-6-nitro-2H-indazole is an impurity in the synthesis of Pazopanib (P210925) hydrochloride, an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

structure and hydrogen bonding

In the mol-ecule of 2,3-dimethyl-6-nitro-2H-indazole, C9H9N3O2, the indazole ring system is almost planar [maximum deviation = 0.019 (3) Å for the C atom bearing the nitro group]. In the crystal structure, inter-molecular C—H...O inter-actions link the mol-ecules into centrosymmetric dimers, forming R 2 2(18) ring motifs. Aromatic π–π contacts between indazole rings [centroid–centroid distances = 3.632 (1) and 3.705 (1)?] may further stabilize the structure[1].

References

[1] Yan Chen, Ping Wei, Zheng Fang. “2,3-Dimethyl-6-nitro-2H-indazole.” Acta crystallographica. Section E, Structure reports online 65 Pt 8 (2009): o1775.

2,3-dimethyl-6-nitro-2H-indazole (444731-73-1)Related Product Information

• 3-Methyl-6-nitroindazole
• 1,3-DiMethyl-6-aMino-1H-indazole
• 3-Methyl-6-nitro-2H-indazole
• Pazopanib Related Compound 3
• 1,3-Dimethyl-6-nitro-1H-indazole
• Pazopanib Related Compound 2
• 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI)
• N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
• Pazopanib
• 2,3-dimethyl-2H-indazol-6-amine hydrochloride
• Pazopanib Hydrochloride
• 2-Ethyl-5-nitrobenzenamine ,98%
• N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
• Pazopanib Impurity 9
• Pazopanib Impurity 10
• Pazopanib Impurity 2
• 2-Methyl-5-nitrobenzenesulfonamide
• 3-AMINO-4-METHYLBENZENESULFONAMIDE