D[LEU4,LYS8]-VP Chemical Properties

Boiling point:

1493.5±65.0 °C(Predicted)

Density 

1.260±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

pka

9.90±0.15(Predicted)

form 

Powder

Water Solubility 

Soluble to 2 mg/ml in water

Sequence

{Mpa}-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly (Disulfide bridge:Mpa1-Cys6)

D[LEU4,LYS8]-VP Usage And Synthesis

Uses

D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].

References

[1] Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46. DOI:10.1210/en.2006-1633
[2] Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47. DOI:10.1021/jm060928n

D[LEU4,LYS8]-VP(42061-33-6)Related Product Information

• 3-MERCAPTOPROPIONYL-BETA-3-PYRIDYL-D-ALA-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
• 3-MERCAPTO-3-METHYL-BUTYRYL-TYR(ME)-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
• 3-MERCAPTOPROPIONYL-TYR-PHE-GLN-ASN-CYS-PRO-LYS-GLY-NH2, (DISULFIDE BOND)
• 3-MERCAPTO-3-METHYL-BUTYRYL-TYR-PHE-VAL-ASN-CYS-PRO-D-ARG-GLY-NH2
• Desmopressin
• (DEAMINO-CYS1,BETA-CYCLOHEXYL-ALA4,ARG8)-VASOPRESSIN
• (DEAMINO-CYS1,D-ORN8)-VASOPRESSIN
• (DEAMINO-CYS1,VAL4,D-ARG8)-VASOPRESSIN
• D[LEU4,LYS8]-VP